gene

HLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

291Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	HLA
Primary Expression	Ca1, Cortex
Pathways	Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
GeneCards	HLA
Human Protein Atlas	HLA
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cardiovascular
Interactions	ABCA7, AGER, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE
KG Connections	291 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HLA["HLA"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"expressed in"| Lymphoma["Lymphoma"]
    style Lymphoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| FERMT2["FERMT2"]
    style FERMT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| RIN3["RIN3"]
    style RIN3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| ZCWPW1["ZCWPW1"]
    style ZCWPW1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| HLA["HLA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PLD3["PLD3"] -->|"associated"| HLA["HLA"]
    style PLD3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ABCA7["ABCA7"] -->|"associated"| HLA["HLA"]
    style ABCA7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SORL1["SORL1"] -->|"associated"| HLA["HLA"]
    style SORL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PICALM["PICALM"] -->|"associated"| HLA["HLA"]
    style PICALM fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style HLA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (154)

Target	Relation	Type	Str
Microglial Function	modulates	process	0.85
microglia	modulates	cell_type	0.80
INPP5D	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
microglia	expressed_in	cell_type	0.70
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Tumor	interacts_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	causes	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
MEF2C	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
RIN3	interacts_with	gene	0.60
SLC24A4	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
SNCA	associated_with	gene	0.60
IL1B	interacts_with	gene	0.60
PDCD1	interacts_with	gene	0.60
IL1B	regulates	gene	0.60
IL6	regulates	gene	0.60
TREM2	regulates	gene	0.60
neurodegeneration	regulates	disease	0.60
TBK1	interacts_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
PINK1	regulates	gene	0.60
TERT	expressed_in	gene	0.60

Incoming (137)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	0.82
CD33	regulates	gene	0.70
UBIQUITIN	therapeutic_target	gene	0.60
PINK1	regulates	gene	0.60
AGING	associated_with	gene	0.60
APOE	inhibits	gene	0.60
CD44	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
CD33	inhibits	gene	0.60
APOE Ε4	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
CHRNE	associated_with	gene	0.60
RNA	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
STAT1	activates	gene	0.60
IFN	activates	gene	0.60
CD38	causes	gene	0.60
CD44	regulates	gene	0.60
ABCA7	expressed_in	gene	0.60
CD2AP	expressed_in	gene	0.60
CD33	expressed_in	gene	0.60
CR1	expressed_in	gene	0.60
EPHA1	expressed_in	gene	0.60
ASC	regulates	gene	0.60
DGKQ	associated_with	gene	0.60
GAK	associated_with	gene	0.60
GBA	associated_with	gene	0.60
CD38	activates	gene	0.60
CD8	activates	gene	0.60
ABCA1	regulates	gene	0.60
CTSB	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
CTSH	regulates	gene	0.60
CX3CR1	interacts_with	gene	0.60
CD4	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
CD8	associated_with	gene	0.60
CD8	regulates	gene	0.60
CD8	biomarker_for	gene	0.60
DRD2	targets	gene	0.60
CD14	interacts_with	gene	0.60
CD24	interacts_with	gene	0.60
CD28	interacts_with	gene	0.60
CD4	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
TUMOR SUPPRESSOR GENES	interacts_with	gene	0.60
TBK1	associated_with	gene	0.60
C9ORF72	associated_with	gene	0.60
FASL	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HLA in their description or question text

No additional research found

HLA

Understanding Entity Pages

Wiki Pages (7)

HLA-A — Major Histocompatibility Complex Class I A

HLA Haplotypes and Neuroinflammatory Profiles in PSP

HLA-DRB1 Protein

HLA-B — Major Histocompatibility Complex Class I B

HLA-DRB1 — MHC Class II DR Beta 1

HLA-DRB1 Gene