gene

CHRNE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

CHRNE is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHRNE
Full Name	Cholinergic Receptor Nicotinic Epsilon Subunit
Chromosome	17p13.2
Function	CHRNE encodes the epsilon subunit of nicotinic receptors at the NMJ.
Primary Expression	the brain and play roles in cognitive function, attention, and motor control
Pathways	Wnt
UniProt ID	[P30530](https://www.uniprot.org/uniprotkb/P30530/entry)
GeneCards	CHRNE
Human Protein Atlas	CHRNE
Associated Diseases	Als, Alzheimer, Ms
Interactions	ASTROCYTE, CASS4, Cytokine, CYTOKINES, GENES, IL13
KG Connections	89 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHRNE Gene

gene · 667 words

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Pathway Diagram

graph TD
    CHRNE["CHRNE"]
    Ms{"Ms"}
    CHRNE -->|"associated with"| Ms
    Alzheimer{"Alzheimer"}
    CHRNE -->|"associated with"| Alzheimer
    Als{"Als"}
    CHRNE -->|"associated with"| Als
    AND["AND"]
    CHRNE -->|"associated with"| AND
    AMYLOID["AMYLOID"]
    CHRNE -->|"associated with"| AMYLOID
    neurodegeneration["neurodegeneration"]
    CHRNE -->|"implicated in"| neurodegeneration
    APP["APP"]
    APP -->|"associated with"| CHRNE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| CHRNE
    NDUFAF7["NDUFAF7"]
    NDUFAF7 -->|"associated with"| CHRNE
    SHARPIN["SHARPIN"]
    SHARPIN -->|"associated with"| CHRNE
    APOE["APOE"]
    APOE -->|"associated with"| CHRNE
    PLCG2["PLCG2"]
    PLCG2 -->|"associated with"| CHRNE
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| CHRNE
    style CHRNE fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
CD33	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
GRM2	expressed_in	gene	0.60
CASS4	associated_with	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
ADRA2B	expressed_in	gene	0.60
CR1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
WNT1	activates	gene	0.60
Rb	expressed_in	protein	0.60
DES	causes	gene	0.60
AMYLOID	associated_with	gene	0.60
GABA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
Ras	causes	protein	0.60
GRIN3B	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HLA	associated_with	gene	0.60
Cytokine	activates	protein	0.60
WNT11	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
MICROGLIA	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
Monocyte	associated_with	cell_type	0.60
Microglia	associated_with	cell_type	0.60
AND	expressed_in	gene	0.60
GENES	activates	gene	0.60
Brainstem	expressed_in	brain_region	0.55
Microglia	expressed_in	cell_type	0.55
Ca1	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
CLU	co_expressed_with	gene	0.50

Incoming (37)

Source	Relation	Type	Str
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
BIN1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TNFRSF13C	activates	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
WNT11	activates	gene	0.60
MACF1	causes	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
APP	associated_with	gene	0.60
NDUFAF7	associated_with	gene	0.60
SHARPIN	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CR1	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CASS4	interacts_with	gene	0.50
acetylcholine	expressed_in	disease	0.50
CD33	co_expressed_with	gene	0.50
GABA	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHRNE in their description or question text

No additional research found