disease

migraine

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about migraine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

236Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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Disease Info

HTR1A	Autoreceptor (somatodendritic) controlling firing rate
HTR1B	Autoreceptor (terminal) inhibiting release
HTR2A	Postsynaptic excitatory receptor
HTR2C	Postsynaptic receptor modulating pain and mood
HTR7	Postsynaptic excitatory receptor in circadian regulation
Associated Genes	EPHA5, RPL17
KG Connections	9 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Serotonergic Raphe Neurons in Migraine

cell · 811 words

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Pathway Diagram

graph TD
    MIGRAINE["MIGRAINE"]
    Oxidative_stress["Oxidative stress"] -->|"causes"| MIGRAINE
    Cerebral_energy_deficiency["Cerebral energy deficiency"] -->|"causes"| MIGRAINE
    CCL3["CCL3"] -->|"activates"| MIGRAINE
    C1Q["C1Q"] -->|"activates"| MIGRAINE
    CHR2["CHR2"] -->|"activates"| MIGRAINE
    TNF["TNF"] -->|"regulates"| MIGRAINE
    GENES["GENES"] -->|"activates"| MIGRAINE
    MICROGLIA["MICROGLIA"] -->|"regulates"| MIGRAINE
    ASTROCYTES["ASTROCYTES"] -->|"regulates"| MIGRAINE
    IL_6["IL-6"] -->|"regulates"| MIGRAINE

Outgoing (75)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
NEURODEGENERATION	interacts_with	disease	0.65
CHOLESTEROL	regulates	phenotype	0.65
Blood-Brain Barrier	therapeutic_target	pathway	0.60
unfolded protein response	involves	pathway	0.60
neurons	affects	cell_type	0.60
Angiogenesis	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
MULTIPLE SCLEROSIS	activates	disease	0.60
NEURODEGENERATION	causes	disease	0.60
Apoptosis	activates	pathway	0.60
nitric oxide	disrupts	neurotransmitter	0.60
Notch	contributes_to	pathway	0.60
ferroptosis	involves	pathway	0.60
Dementia	contributes_to	disease	0.55
Glaucoma	activates	disease	0.55
Amyloid	activates	pathway	0.55
Inflammasome	activates	pathway	0.55
Neuroinflammatory	regulates	pathway	0.55
Cell Cycle	regulates	pathway	0.55
Ferroptosis	regulates	pathway	0.55
Calcium Signaling	regulates	pathway	0.55
Astrocyte	regulates	cell_type	0.55
Autism	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Multiple Sclerosis	associated_with	disease	0.55
Neutrophil	associated_with	cell_type	0.55
Dendritic Cell	associated_with	cell_type	0.55
Circadian Rhythm	activates	pathway	0.55
Circadian Rhythm	therapeutic_target	pathway	0.55
Cell Cycle	associated_with	pathway	0.55
Macrophage	associated_with	cell_type	0.55
Calcium Signaling	associated_with	pathway	0.55
Alzheimer	therapeutic_target	disease	0.55
Huntington	associated_with	disease	0.55
Neuron	activates	cell_type	0.55
Microglia	activates	cell_type	0.55
Cholesterol	activates	pathway	0.55
Inflammation	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Alzheimer	activates	disease	0.55
Neurodegeneration	activates	disease	0.55
Pain	regulates	disease	0.50
Pain	expressed_in	disease	0.50
NUCLEUS	expressed_in	concept	0.50

Incoming (161)

Source	Relation	Type	Str
EPHA5	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.75
Niacin	treats	drug	0.75
Oxidative stress	causes	process	0.70
Cerebral energy deficiency	causes	process	0.70
Cerebral energy metabolism	associated_with	process	0.70
RPL17	associated_with	gene	0.70
MICROGLIA	activates	gene	0.65
BDNF	activates	gene	0.65
TRKB	activates	gene	0.65
CX3CR1	activates	gene	0.65
ASTROCYTES	contributes_to	gene	0.65
NF-ΚB	activates	gene	0.65
ASTROCYTE	contributes_to	gene	0.65
CYTOKINES	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
NEURODEGENERATION	regulates	gene	0.65
GENES	regulates	gene	0.65
RNA	expressed_in	gene	0.65
HUB GENES	regulates	gene	0.65
FERROPTOSIS	regulates	gene	0.65
IMMUNE INFILTRATION	regulates	gene	0.65
CCL3	activates	gene	0.65
C1Q	activates	gene	0.65
BMAL1	activates	gene	0.65
CIRCADIAN RHYTHM	activates	gene	0.65
TRPA1	inhibits	gene	0.65
SRC	regulates	gene	0.65
SCN8A	inhibits	gene	0.65
AKT1	inhibits	gene	0.65
TRPM3	inhibits	gene	0.65
CREBBP	inhibits	gene	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.65
DEPRESSION	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
PARKINSON'S DISEASE	associated_with	gene	0.65
PARKINSON	associated_with	gene	0.65
EPILEPSY	associated_with	gene	0.65
HUNTINGTON'S DISEASE	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
INFLAMMATION	associated_with	gene	0.65
FOS	activates	gene	0.65
C-FOS	activates	gene	0.65
SIRT1	regulates	gene	0.65
EPILEPSY	therapeutic_target	gene	0.65
PARKINSON	therapeutic_target	gene	0.65
ALZHEIMER	therapeutic_target	gene	0.65
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.65
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.65
NTS	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning migraine in their description or question text

No additional research found