Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABA-A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GABA |
| Chromosome | 12p12.3 |
| Function | is a hallmark of neurodegeneration. |
| Primary Expression | hippocampus, cortex, cerebellum, thalamus, hypothalamus |
| Amino Acids | 602 aa |
| Exons | 14 |
| Pathways | GABAergic Signaling |
| GeneCards | GABA |
| Human Protein Atlas | GABA |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCA7, ACTB, Actin, Akt, AKT, AKT1 |
| KG Connections | 1381 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GABA_A["GABA-A"]
Depression{"Depression"}
GABA_A -->|"activates"| Depression
Migraine{"Migraine"}
GABA_A -->|"activates"| Migraine
Huntington{"Huntington"}
GABA_A -->|"activates"| Huntington
Schizophrenia{"Schizophrenia"}
GABA_A -->|"activates"| Schizophrenia
Parkinson{"Parkinson"}
GABA_A -->|"activates"| Parkinson
Alzheimer{"Alzheimer"}
GABA_A -->|"activates"| Alzheimer
Caffeine["Caffeine"]
Caffeine -->|"interacts_with"| GABA_A
PARKINSON(["PARKINSON"])
PARKINSON -->|"activates"| GABA_A
HUNTINGTON(["HUNTINGTON"])
HUNTINGTON -->|"activates"| GABA_A
ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
ALZHEIMER_S_DISEASE -->|"activates"| GABA_A
style GABA_A fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Huntington | activates | disease | 0.65 |
| Schizophrenia | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Migraine | activates | disease | 0.65 |
| App | activates | protein | 0.60 |
| EPILEPSY | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| HUNTINGTON'S DISEASE | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Actin | activates | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| HUNTINGTON | activates | gene | 0.60 |
| EPILEPSY | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| GABA | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GABA-A in their description or question text
No additional research found