concept

INOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INOS
Key Genes/Proteins	ABCA7, Actin, AGING, AIF, AIF1, Akt
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER'S DISEASE
Related Pathways	Alpha-Synuclein

Pathway Diagram

graph TD
    INOS["INOS"]
    style INOS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INOS -->|"activates"| Tumor["Tumor"]
    INOS -->|"activates"| Parkinson["Parkinson"]
    INOS -->|"activates"| Inflammation["Inflammation"]
    INOS -->|"expressed in"| ALS["ALS"]
    INOS -->|"activates"| Alzheimer["Alzheimer"]
    INOS -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    INOS -->|"activates"| Huntington["Huntington"]
    INOS -->|"activates"| Neurodegeneration["Neurodegeneration"]
    INOS -->|"activates"| Ischemia["Ischemia"]
    TNF([TNF]) -.->|"inhibits"| INOS
    TGM2([TGM2]) -->|"co_expressed_with"| INOS
    IL_10([IL-10]) -->|"expressed in"| INOS
    CATALASE([CATALASE]) -->|"activates"| INOS
    OXIDATIVE_STRESS([OXIDATIVE STRESS]) -->|"activates"| INOS
    ROS([ROS]) -->|"activates"| INOS
    NRF1([NRF1]) -->|"activates"| INOS
    INFLAMMATION([INFLAMMATION]) -->|"activates"| INOS
    BDNF([BDNF]) -->|"expressed in"| INOS

Outgoing (251)

Target	Relation	Type	Str
Neurodegeneration	contributes_to	process	0.90
M1 pro-inflammatory phenotype	biomarker_for	cell_type	0.70
Als	expressed_in	disease	0.65
Autoimmune	activates	disease	0.65
Inflammation	protects_against	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
Stroke	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	biomarker_for	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Ischemia	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Depression	activates	disease	0.65
Als	inhibits	disease	0.65
Als	regulates	disease	0.65
P38	degrades	gene	0.60
ERK	degrades	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BAX	degrades	gene	0.60
Apoptosis	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Nf-Κb	degrades	pathway	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ABCA7	regulates	gene	0.60
NDUFA1	regulates	gene	0.60
Nf-Κb	associated_with	pathway	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60

Incoming (172)

Source	Relation	Type	Str
NF-KB	associated_with	protein	0.96
Lipopolysaccharide	upregulates	compound	0.95
ASTROCYTES	expressed_in	cell_type	0.90
TG2	associated_with	gene	0.85
ROS	regulates	process	0.85
BIG1	upregulates	gene	0.85
CASTRATION	upregulates	biological_process	0.80
DHT	inhibits	compound	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.80
Microglia-like cells	downregulates	cell_type	0.80
TREM2	upregulates	gene	0.80
CASP3	associated_with	gene	0.72
TNF	associated_with	gene	0.72
PARKINSON'S DISEASE	associated_with	disease	0.72
TNF	inhibits	gene	0.64
GASTRODIN	activates	gene	0.60
STAT3	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
RIPK2	activates	gene	0.60
NOD2	activates	gene	0.60
IL-1	activates	gene	0.60
APOPTOSIS	protects_against	gene	0.60
IL-1	expressed_in	gene	0.60
AIF1	biomarker_for	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
CYBB	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
PER	activates	gene	0.60
GFAP	expressed_in	gene	0.60
TRAF6	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
NLRP3	inhibits	gene	0.60
HMGB1	inhibits	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
GSH	therapeutic_target	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
IL-1	inhibits	gene	0.60
IL-4	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
CYTC	degrades	gene	0.60
ASTROCYTE	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BCL-2	degrades	gene	0.60
TNF	degrades	gene	0.60
CYTOKINES	inhibits	gene	0.60
GFAP	degrades	gene	0.60
NF-ΚB	degrades	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INOS in their description or question text

No additional research found