gene

CYTC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYTC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

Summary

CYTC is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, expressed in. Associated with Als, Cardiac, Cardiovascular. Connected to 66 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CYTC
Chromosome	7p14.3
Protein Type	Protease
Function	Serves as an electron carrier between Complex III (cytochrome bc1 complex) and Complex IV (cytochrome c oxidase)
Amino Acids	104 aa
Pathways	Endocytosis
UniProt ID	P99999
NCBI Gene ID	9377
Ensembl ID	ENSG00000109854
GeneCards	CYTC
Human Protein Atlas	CYTC
Location	Resides in the intermembrane space, loosely associated with inner mitochondrial membrane
Heme Group	Contains covalently attached heme c (bis-histidine heme) essential for electron transfer
Redox Potential	Exhibits midpoint potential of +0.22 V, enabling efficient electron transfer
Associated Diseases	Als
Interactions	APOPTOSIS, ASTROCYTE, ASTROCYTES, BAX, BCL-2, Cytokine
KG Connections	115 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CYTC — AlphaFold P99999 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CYTC

gene · 1885 words

→

Pathway Diagram

graph TD
    CYTC["CYTC"]
    Inflammation{"Inflammation"}
    CYTC -->|"inhibits"| Inflammation
    Stroke{"Stroke"}
    CYTC -->|"inhibits"| Stroke
    Ischemia{"Ischemia"}
    CYTC -->|"inhibits"| Ischemia
    Ms{"Ms"}
    CYTC -->|"inhibits"| Ms
    GFAP["GFAP"]
    CYTC -->|"expressed in"| GFAP
    Apoptosis(["Apoptosis"])
    CYTC -->|"inhibits"| Apoptosis
    Nf__b(["Nf-Kappab"])
    CYTC -->|"expressed in"| Nf__b
    Mapk(["Mapk"])
    CYTC -->|"inhibits"| Mapk
    neurodegeneration["neurodegeneration"]
    CYTC -->|"implicated in"| neurodegeneration
    P38["P38"]
    P38 -->|"expressed in"| CYTC
    ERK["ERK"]
    ERK -->|"expressed in"| CYTC
    TNF["TNF"]
    TNF -->|"expressed in"| CYTC
    BAX["BAX"]
    BAX -->|"expressed in"| CYTC
    BCL_2["BCL-2"]
    BCL_2 -->|"expressed in"| CYTC
    style CYTC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (76)

Target	Relation	Type	Str
Apoptosis	inhibits	pathway	0.70
APAF1	participates_in	protein	0.70
Cardiac	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Als	regulates	disease	0.65
Infection	inhibits	disease	0.65
Als	causes	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Glioma	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
GFAP	expressed_in	gene	0.60
P62	regulates	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
Mapk	inhibits	pathway	0.60
ASTROCYTES	inhibits	gene	0.60
BCL2	regulates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
BCL-2	expressed_in	gene	0.60
STROKE	inhibits	gene	0.60
BCL2	treats	gene	0.60
IL-1	degrades	gene	0.60
Caspase	degrades	protein	0.60
Cytokine	inhibits	protein	0.60
Fus	inhibits	protein	0.60
HO-1	associated_with	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
BCL-2	regulates	gene	0.60
Apoptosis	associated_with	pathway	0.60
Il-1	degrades	protein	0.60
BAX	expressed_in	gene	0.60
Endocytosis	activates	pathway	0.60
LC3B	regulates	gene	0.60
GFAP	degrades	gene	0.60
P38	degrades	gene	0.60
BAX	degrades	gene	0.60
BCL-2	inhibits	gene	0.60
DGAT2	inhibits	gene	0.60
MTDNA	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNA	activates	gene	0.60
ATP	causes	gene	0.60
NEURON	causes	gene	0.60
Oxidative Phosphorylation	causes	pathway	0.60
Differentiation	causes	pathway	0.60

Incoming (39)

Source	Relation	Type	Str
APOPTOSIS	inhibits	gene	0.70
ERK	expressed_in	gene	0.60
BCL-2	expressed_in	gene	0.60
CYTOKINES	inhibits	gene	0.60
NF-ΚB	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF-Α	expressed_in	gene	0.60
ASTROCYTE	inhibits	gene	0.60
GFAP	degrades	gene	0.60
IL-1	expressed_in	gene	0.60
APAF1	regulates	gene	0.60
CASPASE3	regulates	gene	0.60
BECLIN1	regulates	gene	0.60
ATG5	regulates	gene	0.60
BAX	regulates	gene	0.60
BNIP3	regulates	gene	0.60
P38	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
BAX	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
CAT	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
ROS	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
INOS	degrades	gene	0.60
BAX	inhibits	gene	0.60
PLIN2	inhibits	gene	0.60
BAX	causes	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
BCL-2	degrades	gene	0.60
IL-1	degrades	gene	0.60
GFAP	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYTC in their description or question text

No additional research found