concept

BIG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

16Outgoing

2Incoming

0Experiments

0Debates

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💡 Concept Info

Name	BIG1
Key Genes/Proteins	IL-1β, IL-6, KLF4, PI3K, TNF, TNF-α
Related Diseases	Cell Migration
Related Pathways	NF-kB signaling, PI3K-AKT-mTOR signaling, PI3K/Akt/NF-kB Signaling Pathway

Pathway Diagram

graph TD
    BIG1[BIG1]
    BIG1 -->|activates| PI3K_Akt_NF_kB_Signaling_Pathw[PI3K/Akt/NF-kB Signaling Pathway]
    BIG1 -->|upregulates| iNOS[iNOS]
    BIG1 -->|upregulates| COX_2[COX-2]
    BIG1 -->|upregulates| TNF__[TNF-α]
    BIG1 -->|upregulates| IL_1_[IL-1β]
    BIG1 -->|upregulates| IL_6[IL-6]
    BIG1 -->|expressed in| TNF[TNF]
    BIG1 -->|activates| PI3K[PI3K]
    BIG1 -->|activates| KLF4[KLF4]
    KLF4 -->|regulates| BIG1
    benchmark_ot_ad_answer_key_BIG[benchmark_ot_ad_answer_key:BIG1] -->|data_in| BIG1

Outgoing (16)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BIG1	data_in	dataset_row	0.00
PI3K/Akt/NF-kB Signaling Pathway	activates	pathway	0.90
Cell Migration	associated_with	phenotype	0.90
iNOS	upregulates	enzyme	0.85
COX-2	upregulates	enzyme	0.85
TNF-α	upregulates	protein	0.85
IL-1β	upregulates	protein	0.85
IL-6	upregulates	protein	0.85
TNF	expressed_in	gene	0.60
PI3K	activates	gene	0.60
PI3K	associated_with	gene	0.60
KLF4	activates	gene	0.60
KLF4	regulates	gene	0.60
PI3K	regulates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BIG1	data_in	dataset_row	0.00
KLF4	regulates	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BIG1 in their description or question text

No additional research found