concept

DHT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

1Hypotheses

0Analyses

31Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DHT
Key Genes/Proteins	Aβ, Bax, Bcl-2, BCL2, CASP3, Caspase-3
Related Diseases	Alzheimer'S Disease
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    DHT[DHT]
    DHT -->|inhibits| Neuroinflammation[Neuroinflammation]
    DHT -->|inhibits| TLR4[TLR4]
    DHT -->|downregulates| Tnf__[Tnf-Α]
    DHT -->|downregulates| Il_1_[Il-1Β]
    DHT -->|downregulates| IL_6[IL-6]
    DHT -->|causes| PCOS_like_Phenotype[PCOS-like Phenotype]
    DHT -.protects against.-> Neuronal_Damage[Neuronal Damage]
    DHT -->|inhibits| iNOS[iNOS]
    DHT -->|inhibits| COX_2[COX-2]
    DHT -->|inhibits| NO[NO]
    Castration[Castration] -->|downregulates| DHT

Outgoing (31)

Target	Relation	Type	Str
neuroinflammation	inhibits	process	0.95
Neuroinflammation	inhibits	process	0.95
TLR4	inhibits	protein	0.90
IL-6	downregulates	protein	0.90
Il-1Β	downregulates	protein	0.90
Tnf-Α	downregulates	protein	0.90
PCOS-like Phenotype	causes	phenotype	0.86
neuronal damage	protects_against	process	0.85
Neuronal Damage	protects_against	phenotype	0.85
IL-13	upregulates	protein	0.80
Aβ	regulates	protein	0.80
IL-1β	inhibits	protein	0.80
IL-6	inhibits	protein	0.80
IL-10	upregulates	protein	0.80
iNOS	inhibits	protein	0.80
PGE2	inhibits	compound	0.80
SH-SY5Y	protects_against	cell_type	0.80
Caspase-3	regulates	protein	0.80
Bcl-2	regulates	protein	0.80
Bax	regulates	protein	0.80
Synaptophysin	regulates	protein	0.80
COX-2	inhibits	protein	0.80
NO	inhibits	compound	0.80
IL-10	modulates	protein	0.75
IL-13	modulates	protein	0.75
Alzheimer'S Disease	protects_against	disease	0.75
CASP3	modulates	protein	0.70
NF-κB	inhibits	pathway	0.70
TNF-α	inhibits	protein	0.70
BCL2	regulates	protein	0.70
MAPK p38	inhibits	pathway	0.70

Incoming (1)

Source	Relation	Type	Str
Castration	downregulates	process	0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Testosterone-Derived DHT Amplifies Microglial Androgen Recep	0.490	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHT in their description or question text

No additional research found