gene

RGS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RGS4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, upregulates, implicated in. Associated with ALS, Als, Bipolar. Connected to 60 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RGS4
Chromosome	1q23.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Prefrontal cortex, Striatum, Hippocampus
Molecular Weight	24 kDa
Amino Acids	206 aa
Pathways	Amyloid, Apoptosis, Oxidative Stress
UniProt ID	P49798
NCBI Gene ID	5999
Ensembl ID	ENSG00000117408
OMIM	602514
GeneCards	RGS4
Human Protein Atlas	RGS4
Associated Diseases	Als, Bipolar, Depression, Ms, Schizophrenia
Interactions	AKT, BACE1, CNR1, DAO, DISC1, G72
KG Connections	127 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RGS4 — AlphaFold P49798 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RGS4 Gene

gene · 874 words

→

RGS4 Protein

protein · 592 words

→

Pathway Diagram

graph TD
    RGS4["RGS4"]
    TREM2["TREM2"]
    RGS4 -->|"upregulates"| TREM2
    MHC_I["MHC-I"]
    RGS4 -->|"upregulates"| MHC_I
    Schizophrenia{"Schizophrenia"}
    RGS4 -->|"associated with"| Schizophrenia
    Als{"Als"}
    RGS4 -->|"associated with"| Als
    Depression{"Depression"}
    RGS4 -->|"associated with"| Depression
    Bipolar{"Bipolar"}
    RGS4 -->|"associated with"| Bipolar
    Ms{"Ms"}
    RGS4 -->|"associated with"| Ms
    ALS{"ALS"}
    RGS4 -->|"associated with"| ALS
    GRIN2B["GRIN2B"]
    RGS4 -->|"associated with"| GRIN2B
    DRD1["DRD1"]
    RGS4 -->|"associated with"| DRD1
    TPH2["TPH2"]
    RGS4 -->|"associated with"| TPH2
    GABRA5["GABRA5"]
    RGS4 -->|"associated with"| GABRA5
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| RGS4
    DISC1["DISC1"]
    DISC1 -->|"associated with"| RGS4
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| RGS4
    NRG1["NRG1"]
    NRG1 -->|"associated with"| RGS4
    DAO["DAO"]
    DAO -->|"associated with"| RGS4
    BMAL1["BMAL1"]
    BMAL1 -->|"associated with"| RGS4
    GRM4["GRM4"]
    GRM4 -->|"associated with"| RGS4
    SYNGR1["SYNGR1"]
    SYNGR1 -->|"associated with"| RGS4
    BDNF["BDNF"]
    BDNF -->|"associated with"| RGS4
    NCAM1["NCAM1"]
    NCAM1 -->|"associated with"| RGS4
    HTTLPR["HTTLPR"]
    HTTLPR -->|"associated with"| RGS4
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"associated with"| RGS4
    style RGS4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (76)

Target	Relation	Type	Str
MHC-I	upregulates	protein	0.80
TREM2	upregulates	gene	0.80
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
TPH2	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
NEFL	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
Transferrin	regulates	protein	0.60
Rb	regulates	protein	0.60
schizophrenia	interacts_with	disease	0.60
BACE1	regulates	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ERBB2	regulates	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Amyloid	regulates	pathway	0.60
App	expressed_in	protein	0.60
Circadian Rhythm	associated_with	pathway	0.60
TAU	expressed_in	gene	0.60
NEFM	regulates	gene	0.60
CNR1	regulates	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
HTTLPR	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
G72	associated_with	gene	0.60

Incoming (51)

Source	Relation	Type	Str
genes-rgs4	linked_to	wiki	1.00
NEFL	regulates	gene	0.60
AKT	regulates	gene	0.60
BACE1	inhibits	gene	0.60
AKT	inhibits	gene	0.60
BACE1	regulates	gene	0.60
G72	interacts_with	gene	0.60
ERBB2	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
POLG	associated_with	gene	0.60
DNA	associated_with	gene	0.60
GENES	regulates	gene	0.60
MTDNA	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
RAS	regulates	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
NEFM	regulates	gene	0.60
CNR1	regulates	gene	0.60
TAU	expressed_in	gene	0.60
DAO	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
GRIN2B	interacts_with	gene	0.60
GRM3	interacts_with	gene	0.60
GRM4	interacts_with	gene	0.60
NCAM1	interacts_with	gene	0.60
NRG1	interacts_with	gene	0.60
HTTLPR	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
G72	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
NEFM	interacts_with	gene	0.50
POLG	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RGS4 in their description or question text

No additional research found