concept

COLLAGEN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COLLAGEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	COLLAGEN

Pathway Diagram

graph TD
    COLLAGEN["COLLAGEN"]
    style COLLAGEN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    COLLAGEN -->|"activates"| Neuroinflammation["Neuroinflammation"]
    COLLAGEN -->|"activates"| Stroke["Stroke"]
    COLLAGEN -->|"target for"| Cancer["Cancer"]
    COLLAGEN -->|"expressed in"| Als["Als"]
    COLLAGEN -.->|"inhibits"| Ferroptosis["Ferroptosis"]
    COLLAGEN -->|"activates"| Fibrosis["Fibrosis"]
    COLLAGEN -->|"encodes"| Glioblastoma["Glioblastoma"]
    COLLAGEN -->|"activates"| Aging["Aging"]
    VWF([VWF]) -->|"interacts"| COLLAGEN
    MMP1([MMP1]) -.->|"degrades"| COLLAGEN
    myofibroblasts["/myofibroblasts/"] -->|"produces"| COLLAGEN
    NRF2([NRF2]) -->|"activates"| COLLAGEN
    STROKE([STROKE]) -->|"activates"| COLLAGEN
    AMPK([AMPK]) -->|"activates"| COLLAGEN
    CD68([CD68]) -->|"activates"| COLLAGEN
    CX3CR1([CX3CR1]) -->|"activates"| COLLAGEN
    CD36([CD36]) -->|"activates"| COLLAGEN
    MICROGLIA([MICROGLIA]) -->|"activates"| COLLAGEN

Outgoing (67)

Target	Relation	Type	Str
Als	expressed_in	disease	0.60
Anxiety	activates	disease	0.60
Alzheimer	activates	disease	0.60
Senescence	activates	disease	0.60
Senescence	associated_with	disease	0.60
Aging	interacts_with	disease	0.60
Anxiety	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Alzheimer	expressed_in	disease	0.60
Als	activates	disease	0.60
Glioblastoma	encodes	disease	0.60
Aging	activates	disease	0.60
Fibrosis	inhibits	disease	0.60
Als	inhibits	disease	0.60
Als	interacts_with	disease	0.60
Aging	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Ferroptosis	inhibits	disease	0.60
Stroke	activates	disease	0.60
Fibrosis	activates	disease	0.60
Glioblastoma	therapeutic_target	disease	0.60
Cancer	therapeutic_target	disease	0.60
Cerebral Amyloid Angiopathy	associated_with	disease	0.60
Diabetes	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Als	regulates	disease	0.60
Pyroptosis	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Aging	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Hypertension	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Cancer	activates	disease	0.60
Mtor	inhibits	pathway	0.55
Nf-Kb	activates	pathway	0.55
Cholesterol	activates	pathway	0.55
Nf-Κb	inhibits	pathway	0.55
Mitophagy	activates	pathway	0.55
Mitochondrial Function	activates	pathway	0.55
Autophagy	inhibits	pathway	0.55
Pi3K/Akt	inhibits	pathway	0.55
Wnt	activates	pathway	0.55
Pi3K/Akt	activates	pathway	0.55
Inflammasome	activates	pathway	0.55
Interferon Signaling	activates	pathway	0.55
Wnt	inhibits	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Lipid Metabolism	activates	pathway	0.55

Incoming (149)

Source	Relation	Type	Str
VWF	interacts_with	protein	0.95
MMP1	degrades	gene	0.80
myofibroblasts	produces	cell_type	0.72
MICROGLIA	activates	gene	0.60
PPAR	activates	gene	0.60
TNF	activates	gene	0.60
IL-1	activates	gene	0.60
CD163	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
LOX/LOXL1-4	therapeutic_target	gene	0.60
LOXL3	therapeutic_target	gene	0.60
ATF4	regulates	gene	0.60
WNT	regulates	gene	0.60
RANKL	regulates	gene	0.60
RANK	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
RUNX2	regulates	gene	0.60
STAT3	activates	gene	0.60
PDGFRB	activates	gene	0.60
AGING	expressed_in	gene	0.60
WNT	expressed_in	gene	0.60
CERS2	activates	gene	0.60
SPTLC1	activates	gene	0.60
APP/PS1	activates	gene	0.60
EXERCISE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
WNT	activates	gene	0.60
AKT	activates	gene	0.60
THBS2	activates	gene	0.60
PIEZO1	activates	gene	0.60
MTDNA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
DNA	activates	gene	0.60
RPTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COLLAGEN in their description or question text

No additional research found