concept

ENTORHINAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENTORHINAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

4Hypotheses

0Analyses

45Outgoing

23Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ENTORHINAL
Key Genes/Proteins	APOE, APP
Related Diseases	ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alzheimer's Disease Neuroimaging Initiative (ADNI)

dataset · 606 words

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Pathway Diagram

graph TD
    ENTORHINAL["ENTORHINAL"]
    ENTORHINAL -->|"reduces"| WHITE_MATTER["WHITE MATTER"]
    ENTORHINAL -->|"sensitizes_to"| GFAP["GFAP"]
    ENTORHINAL -->|"inhibits"| MICROGLIA["MICROGLIA"]
    ENTORHINAL -->|"inhibits"| P2RX7["P2RX7"]
    ENTORHINAL -->|"inhibits"| TAU_PROPAGATION["TAU PROPAGATION"]
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| ENTORHINAL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ENTORHINAL
    CORTEX["CORTEX"] -->|"causes"| ENTORHINAL
    AMYLOID["AMYLOID"] -->|"causes"| ENTORHINAL

Outgoing (45)

Target	Relation	Type	Str
WHITE MATTER	reduces	brain_region	0.65
GFAP	sensitizes_to	gene	0.65
P2RX7	inhibits	gene	0.60
MICROGLIA	inhibits	cell_type	0.60
TFEB	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
SIRT1	co_discussed	entity	0.50
FUS	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
GLUCOSE METABOLISM	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
P2RX7	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
INTERNEURON	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
STRIATUM	co_discussed	entity	0.50
INTERNEURONS	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
TAU PROPAGATION	co_discussed	entity	0.50
PREFRONTAL	co_discussed	entity	0.50
SEEDING	co_discussed	entity	0.50
LOCUS COERULEUS	co_discussed	entity	0.50
GRN	co_discussed	entity	0.50
HSP90	co_discussed	entity	0.50
P62	co_discussed	entity	0.50
FRONTOTEMPORAL	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
NEURON	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
NEURODEGENERATION	co_discussed	disease	0.40
IBA1	co_discussed	gene	0.40
MICROGLIA	co_discussed	cell_type	0.40
FRONTAL	co_discussed	brain_region	0.40
WHITE MATTER	co_discussed	brain_region	0.40
WNT	co_discussed	gene	0.40

Incoming (23)

Source	Relation	Type	Str
CORTEX	associated_with	brain_region	0.65
ASTROCYTE	expressed_in	cell_type	0.65
ASTROCYTES	expressed_in	cell_type	0.65
CORTEX	causes	brain_region	0.60
ASTROCYTE	inhibits	cell_type	0.60
ASTROCYTES	inhibits	cell_type	0.60
BDNF	co_discussed	entity	0.50
AMYGDALA	co_discussed	entity	0.50
BIN1	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
CHOLINERGIC	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
ALZHEIMER	co_discussed	disease	0.40
ALZHEIMER'S	co_discussed	disease	0.40
ALZHEIMER'S DISEASE	co_discussed	disease	0.40
CEREBELLUM	co_discussed	brain_region	0.40
APP	co_discussed	gene	0.40
CA1	co_discussed	brain_region	0.40
APOE	co_discussed	gene	0.40

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
LRP1-mediated synaptic uptake drives early entorhinal-hippoc	0.570	neurodegeneration	Which tau propagation mechanism predomin
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENTORHINAL in their description or question text

No additional research found