concept

WHITE MATTER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WHITE MATTER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

605Connections

11Hypotheses

0Analyses

50Outgoing

50Incoming

7Experiments

0Debates

Summary

WHITE MATTER is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ANXIETY, DEMENTIA. Connected to 36 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	WHITE MATTER
Key Genes/Proteins	ABI3, AKT, AMPK, AMYLOID, APOE, APOE4
Related Diseases	AGING, ALS, ALZHEIMER'S DISEASE, ANXIETY
Related Pathways	AMPK SIGNALING

Pathway Diagram

graph TD
    WHITE_MATTER["WHITE MATTER"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| WHITE_MATTER
    MYELIN["MYELIN"] -->|"expressed in"| WHITE_MATTER
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"expressed in"| WHITE_MATTER
    AQP4["AQP4"] -->|"expressed in"| WHITE_MATTER
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"expressed in"| WHITE_MATTER
    JAM2["JAM2"] -->|"expressed in"| WHITE_MATTER
    JUN["JUN"] -->|"expressed in"| WHITE_MATTER
    GENES["GENES"] -->|"expressed in"| WHITE_MATTER
    XPR1["XPR1"] -->|"expressed in"| WHITE_MATTER
    SLC20A2["SLC20A2"] -->|"expressed in"| WHITE_MATTER

Outgoing (116)

Target	Relation	Type	Str
LIPID PEROXIDATION	causes	phenotype	0.70
PROTEIN AGGREGATION	activates	phenotype	0.70
ALS	treats	disease	0.70
NEURON	stabilizes	cell_type	0.70
APOE	stabilizes	gene	0.70
APOE	regulates	gene	0.70
NEURODEGENERATION	increases_risk	phenotype	0.70
PROTEIN AGGREGATION	stabilizes	phenotype	0.70
APOE	treats	gene	0.70
NECROPTOSIS	regulates	phenotype	0.65
TRAUMATIC BRAIN INJURY	causes	disease	0.65
ALZHEIMER'S DISEASE	regulates	disease	0.65
TREM2	regulates	gene	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
MICROGLIA	associated_with	cell_type	0.65
PSEN1	interacts_with	gene	0.65
FORNIX	stabilizes	brain_region	0.60
TAU	targets	protein	0.60
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
FORNIX	treats	brain_region	0.60
CORPUS CALLOSUM	treats	brain_region	0.60
REMYELINATION	activates	concept	0.50
ISCHEMIC	activates	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
DEMYELINATION	activates	concept	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
REMYELINATION	inhibits	concept	0.50
GLUTAMATE	associated_with	concept	0.50
GLUTAMATE	inhibits	concept	0.50
OLIGODENDROCYTES	activates	concept	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
LACTATE	associated_with	phenotype	0.50
ISCHEMIC	causes	concept	0.50
CELL DEATH	activates	concept	0.50
ENTORHINAL CORTEX	interacts_with	concept	0.50
CHOLESTEROL	associated_with	phenotype	0.50
CYP46A1	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
ISCHEMIC	associated_with	concept	0.50
CSF	associated_with	phenotype	0.50
MOTOR NEURON	activates	concept	0.50
REMYELINATION	causes	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
GRAY MATTER	associated_with	concept	0.50
DEMYELINATION	causes	concept	0.50
GRAY MATTER	causes	concept	0.50
DEMYELINATION	associated_with	concept	0.50
BRAINSTEM	associated_with	concept	0.50
THALAMUS	associated_with	concept	0.50

Incoming (489)

Source	Relation	Type	Str
Aging	causes	process	0.90
multiple sclerosis	affects	disease	0.90
Microglia	associated_with	cell_type	0.88
Microglia Nodules	expressed_in	phenotype	0.88
TAU	associated_with	protein	0.85
neuroinflammation	affects	disease	0.80
neurodegeneration	affects	disease	0.80
aging	affects	disease	0.80
CYP46A1	activates	gene	0.70
ALS	stabilizes	disease	0.70
GRAY MATTER	treats	brain_region	0.70
AGING	stabilizes	phenotype	0.70
MICROGLIAL ACTIVATION	treats	phenotype	0.70
GRAY MATTER	stabilizes	brain_region	0.70
ferroptosis	active_in	pathway	0.70
axon	enriched_in	organelle	0.70
traumatic brain injury	affects	disease	0.70
AGING	treats	phenotype	0.70
MICROGLIA	associated_with	cell_type	0.65
NRF2	promotes	gene	0.65
NEURON	associated_with	cell_type	0.65
GLUTAMATE	transports	phenotype	0.65
MACROPHAGES	causes	cell_type	0.65
NRF2	activates	gene	0.65
STING	activates	gene	0.65
ENTORHINAL	reduces	brain_region	0.65
GLUTAMATE	produces	phenotype	0.65
VEGFA	interacts_with	gene	0.65
CORTEX	reduces	brain_region	0.65
MICROGLIA	protects_against	cell_type	0.65
OLIGODENDROCYTE	causes	cell_type	0.65
BASAL GANGLIA	activates	brain_region	0.65
AGING	exacerbates	phenotype	0.65
OLIGODENDROCYTES	activates	cell_type	0.65
PHAGOCYTOSIS	inhibits	phenotype	0.65
GLUTAMATE	targets	phenotype	0.65
NEURON	expressed_in	cell_type	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
NRF2	regulates	gene	0.65
TRAUMATIC BRAIN INJURY	contributes_to	disease	0.65
TAU	phosphorylates	gene	0.65
CORTEX	phosphorylates	brain_region	0.65
SMPD1	inhibits	gene	0.65
CHOLESTEROL	activates	phenotype	0.65
STROKE	protects_against	disease	0.65
CURCUMIN	treats	drug	0.65
OLIGODENDROCYTES	causes	cell_type	0.65
CHOLESTEROL	causes	phenotype	0.65
ISCHEMIC	causes	disease	0.65
NEURON	activates	cell_type	0.60

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Oligodendrocyte Precursor Cell Senescence in White Matter Di	0.769	-	Senescent cell clearance as neurodegener
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.667	neurodegeneration	Gene expression changes in aging mouse b

Oligodendrocyte White Matter Vulnerability	0.651	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling	0.649	neurodegeneration	Gene expression changes in aging mouse b
White Matter Immune Checkpoint Restoration	0.644	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White	0.600	neurodegeneration	Gene expression changes in aging mouse b
OPC differentiation blockade contributes to white matter deg	0.599	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
TREM2-Mediated Oligodendrocyte-Microglia Signaling in White	0.587	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (7)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice	validation	Alzheimer's disease	0.950	APP/PS1 transgenic mice (8 mon	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	human patients undergoing thor	proposed	N/A
PDGFRA and C-MYC protein validation in ovarian cancer tissues	exploratory	Ovarian cancer	0.850	Human ovarian cancer tissues	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	endocycling mammalian cells	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177]	Lin B, Zhou J, Geng D, Chai S, Zhang X e	Cell Death Differ	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149]	Li C, Teng T, Lin X, Sun X, Yi T et al.	Cancer Res	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
A cellular epigenetic classification system for glioblastoma. [PMID:41499453]	Silverbush D, Jürgensen L, Freeburg NF,	Neuro Oncol	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144]	Daood R, Naffaa ME, Azrilin O, Hassan F,	Clin Rheumatol	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491]	Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan	J Gastroenterol Hepatol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526]	Yan L, Zheng J, Lu Z, Zhu A, Ye M et al.	Circulation	2026
Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834]	Ye D, Zhou H, Qu S, Wang Z, Zhang F et a	Cell Death Discov	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958]	Kim ST, Bass AR	Arthritis Rheumatol	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WHITE MATTER in their description or question text

WHITE MATTER

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (116)

Incoming (489)

Targeting Hypotheses (11)

Mentioning Analyses (0)

Experiments (7)

Related Papers (20)

Debates (0)

Related Research

Oligodendrocyte White Matter Vulnerability

TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur

White Matter Immune Checkpoint Restoration

TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegener

OPC differentiation blockade contributes to white matter degeneration in early-s

TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegenera