concept

ENTORHINAL CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENTORHINAL CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	ENTORHINAL CORTEX
Key Genes/Proteins	AKT, aldh1l1, ALZHEIMER, AMYLOID, AMYLOID-BETA, ANXA2
Related Diseases	AGING, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYLOID PLAQUES

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Entorhinal Cortex

brain · 3091 words

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Pathway Diagram

graph TD
    ENTORHINAL_CORTEX["ENTORHINAL CORTEX"]
    ENTORHINAL_CORTEX -->|"involved_in"| Spatial_Navigation["Spatial Navigation"]
    ENTORHINAL_CORTEX -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    ENTORHINAL_CORTEX -->|"inhibits"| MICROGLIA["MICROGLIA"]
    ENTORHINAL_CORTEX -->|"inhibits"| TAU["TAU"]
    ENTORHINAL_CORTEX -->|"interacts"| WHITE_MATTER["WHITE MATTER"]
    ENTORHINAL_CORTEX -->|"expressed in"| NEURON["NEURON"]
    Neurofibrillary_Tangles["Neurofibrillary Tangles"] -->|"expressed in"| ENTORHINAL_CORTEX
    Impaired_Neuronal_Activity["Impaired Neuronal Activity"] -->|"expressed in"| ENTORHINAL_CORTEX
    Cell_Death["Cell Death"] -->|"involved_in"| ENTORHINAL_CORTEX
    VIMENTIN["VIMENTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ENTORHINAL_CORTEX
    NESTIN["NESTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    SOX2["SOX2"] -->|"expressed in"| ENTORHINAL_CORTEX
    GENES["GENES"] -->|"expressed in"| ENTORHINAL_CORTEX

Outgoing (67)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Memory Impairments	associated_with	phenotype	0.85
Spatial Navigation	involved_in	process	0.80
Mild Cognitive Impairment	involved_in	disease	0.80
tau vulnerability	associated_with	mechanism	0.70
metabolic vulnerability	risk_factor_for	phenotype	0.70
Alzheimer's disease	risk_factor_for	disease	0.70
tau pathology	vulnerability_for	mechanism	0.70
P2RX7	inhibits	gene	0.65
P-TAU	associated_with	protein	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
IDH2	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
PSEN1	associated_with	gene	0.50
CERAMIDE	associated_with	phenotype	0.50
LRP1	associated_with	gene	0.50
PHOSPHO-TAU	associated_with	protein	0.50
EXCITOTOXICITY	associated_with	phenotype	0.50
PRION	associated_with	protein	0.50
SIRT3	associated_with	gene	0.50
MITOPHAGY	associated_with	phenotype	0.50
PINK1	associated_with	gene	0.50
HIPPOCAMPUS	expressed_in	brain_region	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
CELL SURVIVAL	associated_with	phenotype	0.50
AMYLOID-BETA	associated_with	protein	0.50
TREM2	associated_with	gene	0.50
MMSE	associated_with	biomarker	0.50
CSF	associated_with	phenotype	0.50
FDG-PET	associated_with	biomarker	0.50
GRANULE CELLS	associated_with	cell_type	0.50
AQP4	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
NEURON	associated_with	cell_type	0.50
AMYLOID PET	associated_with	biomarker	0.50
MICROGLIA	inhibits	cell_type	0.50
TAU	inhibits	protein	0.50
TAU	associated_with	protein	0.45
TFEB	associated_with	gene	0.45
DEMENTIA	associated_with	disease	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
NEUROGENESIS	associated_with	phenotype	0.45
FUS	associated_with	gene	0.45
IBA1	associated_with	gene	0.45
JNK	associated_with	gene	0.45
TDP-43	associated_with	gene	0.45
WNT PATHWAY	associated_with	pathway	0.45
P2RX7	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45

Incoming (162)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Neurofibrillary Tangles	expressed_in	biomarker	0.90
Impaired Neuronal Activity	expressed_in	phenotype	0.90
AMYLOID	associated_with	protein	0.90
Cell Death	involved_in	process	0.85
LRP-1	expressed_in	gene	0.80
Alzheimer's disease	affects	disease	0.80
NEURONS	causes	cell_type	0.70
neurodegeneration	affects	disease	0.70
GFAP	expressed_in	gene	0.70
HDAC3	inhibits	gene	0.70
AGING	stabilizes	phenotype	0.70
TAU	stabilizes	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
TAU	regulates	protein	0.70
MICROGLIA	associated_with	cell_type	0.66
TAU	causes	protein	0.65
ASTROCYTE	inhibits	cell_type	0.65
TAU	interacts_with	protein	0.65
CA1	inhibits	brain_region	0.65
APP	treats	gene	0.65
CORTEX	treats	brain_region	0.65
TAU	phosphorylates	protein	0.65
TAU	associated_with	protein	0.65
IBA1	expressed_in	gene	0.60
NEURON	depleted_in	cell_type	0.60
HDAC	expressed_in	gene	0.60
FDG-PET	stabilizes	biomarker	0.60
axon	enriched_in	organelle	0.60
APP	expressed_in	gene	0.60
neuroinflammation	affects	disease	0.60
synaptic plasticity	active_in	pathway	0.60
FDG-PET	treats	biomarker	0.60
HSP90AA1	expressed_in	gene	0.60
ASTROCYTES	inhibits	cell_type	0.58
APP	inhibits	gene	0.58
MICROGLIA	inhibits	cell_type	0.56
NOTCH	expressed_in	gene	0.55
APP	participates_in	gene	0.55
APP	associated_with	gene	0.55
AGING	expressed_in	gene	0.55
DEMENTIA	expressed_in	gene	0.55
HUB GENES	expressed_in	gene	0.55
TAU PATHOLOGY	expressed_in	gene	0.55
AMYLOID	expressed_in	gene	0.55
DNA	expressed_in	gene	0.55
ATP	expressed_in	gene	0.55
RNA	expressed_in	gene	0.55
MITOCHONDRIA	expressed_in	gene	0.55
TAUOPATHY	expressed_in	gene	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
Entorhinal Cortex (EC)-Hippocampus Closed-Loop Interface Res	0.510	Alzheimer's disease	Closed-loop optogenetic targeting PV int