concept

SYNAPTIC LOSS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

1Hypotheses

2Analyses

27Outgoing

50Incoming

0Experiments

3Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	SYNAPTIC LOSS
Key Genes/Proteins	AMYLOID
Related Diseases	AGING, ALZHEIMER'S DISEASE, AXONAL TRANSPORT, COGNITIVE DECLINE
Related Pathways	COMPLEMENT CASCADE, COMPLEMENT PATHWAY

Pathway Diagram

graph TD
    SYNAPTIC_LOSS["SYNAPTIC LOSS"]
    SYNAPTIC_LOSS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SYNAPTIC_LOSS -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    SYNAPTIC_LOSS -.biomarker for.-> Depression["Depression"]
    C1q_C3_CR3_signaling_pathway["C1q/C3-CR3 signaling pathway"] -->|"causes"| SYNAPTIC_LOSS
    Abnormal_Microglial_Phagocytos["Abnormal Microglial Phagocytosis"] -->|"causes"| SYNAPTIC_LOSS
    TREM2["TREM2"] -.protects against.-> SYNAPTIC_LOSS
    MICROGLIA["MICROGLIA"] -->|"mediates"| SYNAPTIC_LOSS
    Impaired_Mitophagy["Impaired Mitophagy"] -->|"causes"| SYNAPTIC_LOSS
    Microglial_Phagocytosis["Microglial Phagocytosis"] -->|"causes"| SYNAPTIC_LOSS
    Microglia["Microglia"] -->|"causes"| SYNAPTIC_LOSS
    COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"] -->|"contributes to"| SYNAPTIC_LOSS

Outgoing (27)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.90
Neurodegeneration	contributes_to	process	0.90
Major Depression	contributes_to	disease	0.85
Depression	associated_with	disease	0.85
Depression	biomarker_for	disease	0.80
neurodegeneration	precedes	disease	0.70
network disruption	causes	mechanism	0.70
Cognitive impairment	associated_with	process	0.70
COGNITIVE DECLINE	treats	phenotype	0.70
HIPPOCAMPUS	regulates	brain_region	0.70
HIPPOCAMPUS	activates	brain_region	0.70
NEURODEGENERATION	interacts_with	phenotype	0.65
NEURODEGENERATION	biomarker_for	disease	0.60
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50
AXONAL TRANSPORT	associated_with	phenotype	0.50
CORTEX	associated_with	brain_region	0.50
MELATONIN	associated_with	drug	0.50
MMSE	associated_with	biomarker	0.50
WNT SIGNALING	associated_with	pathway	0.45
AMYGDALA	associated_with	brain_region	0.45
HYPOTHALAMUS	associated_with	brain_region	0.45
THALAMUS	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
DENTATE GYRUS	associated_with	brain_region	0.45

Incoming (58)

Source	Relation	Type	Str
dysfunctional microglial phagocytosis	causes	process	0.92
MICROGLIA	mediates	entity	0.90
C1q/C3-CR3 signaling pathway	causes	pathway	0.90
Microglial Phagocytosis	causes	process	0.90
neuroinflammation	causes	mechanism	0.90
Abnormal Microglial Phagocytosis	causes	process	0.90
Impaired Mitophagy	causes	phenotype	0.90
APOE	downregulates	gene	0.90
SPP1	contributes_to	gene	0.90
Complement-Mediated Microglial Engulfment	causes	process	0.90
Activated Microglia	causes	cell_type	0.88
Microglia	causes	cell_type	0.85
ATAD3A	promotes	protein	0.85
APOE ε2	inhibits	protein	0.85
COMPLEMENT ACTIVATION	contributes_to	entity	0.85
Lipopolysaccharide	causes	compound	0.85
APOE	inhibits	protein	0.85
Inflammasome Signaling	causes	pathway	0.85
SMS1	contributes_to	enzyme	0.82
Complement Activation	contributes_to	process	0.80
ASTROCYTE	causes	cell_type	0.80
BDNF	protects_against	protein	0.80
C3	contributes_to	protein	0.75
OXIDATIVE STRESS	activates	phenotype	0.70
OXIDATIVE STRESS	regulates	phenotype	0.70
COMPLEMENT ACTIVATION	causes	phenotype	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
complement cascade	causes	pathway	0.70
NEUROINFLAMMATION	causes	phenotype	0.70
CORTEX	causes	brain_region	0.70
CORTEX	regulates	brain_region	0.70
AGING	activates	phenotype	0.70
MAC	activates	protein	0.70
NEURONS	treats	cell_type	0.70
AMYLOID	activates	protein	0.70
TAU	activates	protein	0.65
COMPLEMENT PATHWAY	causes	pathway	0.65
ER STRESS	protects_against	phenotype	0.65
HIPPOCAMPUS	causes	brain_region	0.65
MICROGLIA	inhibits	cell_type	0.65
TREM2	causes	gene	0.65
AMYLOID	interacts_with	protein	0.65
NEURON	causes	cell_type	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
TREM2	regulates	gene	0.65
PSEN1	causes	gene	0.65
MICROGLIA	activates	cell_type	0.65
AMYLOID	causes	protein	0.65
TAU	phosphorylates	protein	0.65
NEUROINFLAMMATION	treats	phenotype	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode

Mentioning Analyses (2)

Scientific analyses that reference this entity

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 0 hypotheses

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SYNAPTIC LOSS in their description or question text

No additional research found