concept

PROGRESSIVE SUPRANUCLEAR PALSY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROGRESSIVE SUPRANUCLEAR PALSY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

0Hypotheses

0Analyses

28Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PROGRESSIVE SUPRANUCLEAR PALSY
Key Genes/Proteins	AD, ALS, APP, AQP4, AΒ, BRD4
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, CORTICOBASAL DEGENERATION

Pathway Diagram

graph TD
    PROGRESSIVE_SUPRANUCLEAR_PALSY[PROGRESSIVE SUPRANUCLEAR PALSY]
    PROGRESSIVE_SUPRANUCLEAR_PALSY -->|interacts| MAPT[MAPT]
    PROGRESSIVE_SUPRANUCLEAR_PALSY -->|regulates| INFLAMMATION[INFLAMMATION]
    MAPT -.biomarker for.-> PROGRESSIVE_SUPRANUCLEAR_PALSY
    Tau_Aggregates[Tau Aggregates] -.biomarker for.-> PROGRESSIVE_SUPRANUCLEAR_PALSY
    Ufmylation_Cascade[Ufmylation Cascade] -->|involved_in| PROGRESSIVE_SUPRANUCLEAR_PALSY
    TAU[TAU] -->|produces| PROGRESSIVE_SUPRANUCLEAR_PALSY
    AMYOTROPHIC_LATERAL_SCLEROSIS[AMYOTROPHIC LATERAL SCLEROSIS] -->|produces| PROGRESSIVE_SUPRANUCLEAR_PALSY
    PARKINSON_S_DISEASE[PARKINSON'S DISEASE] -->|interacts| PROGRESSIVE_SUPRANUCLEAR_PALSY
    CORTEX[CORTEX] -->|regulates| PROGRESSIVE_SUPRANUCLEAR_PALSY

Outgoing (28)

Target	Relation	Type	Str
TAU	expresses	gene	0.70
TAU	causes	gene	0.70
TAU	associated_with	gene	0.70
TAU	markers	gene	0.70
MAPT	interacts_with	gene	0.65
INFLAMMATION	regulates	phenotype	0.65
TAU	regulates	gene	0.60
STING	causes	gene	0.60
TAU	activates	gene	0.60
STING	regulates	gene	0.60
TAU	interacts_with	gene	0.60
STING	disrupts	gene	0.60
MAPT	associated_with	gene	0.50
APP	associated_with	gene	0.50
TH	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
BRD4	associated_with	gene	0.50
AQP4	associated_with	gene	0.50
CORTEX	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
TEMPORAL LOBE	associated_with	brain_region	0.45
LOCUS COERULEUS	associated_with	brain_region	0.45
CEREBELLUM	associated_with	brain_region	0.45
BASAL GANGLIA	associated_with	brain_region	0.45
TDP-43	associated_with	gene	0.45
TIDEGLUSIB	associated_with	drug	0.45
STING	co_discussed	gene	0.40
TAU	co_discussed	gene	0.40

Incoming (88)

Source	Relation	Type	Str
MAPT	biomarker_for	protein	0.92
3R/4R Tau Ratio	associated_with	biomarker	0.90
Tau Aggregates	biomarker_for	biomarker	0.85
Ufmylation Cascade	involved_in	pathway	0.80
UFMylation Cascade	associated_with	pathway	0.80
FTD	regulates	disease	0.70
MAPT	regulates	gene	0.70
LEWY BODY DEMENTIA	markers	disease	0.70
LEWY BODY DEMENTIA	regulates	disease	0.70
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.70
NEURONS	associated_with	cell_type	0.70
MAPT	associated_with	gene	0.70
MAPT	causes	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
TAU	produces	protein	0.65
CORTEX	regulates	brain_region	0.65
TAU	interacts_with	protein	0.65
PARKINSON'S DISEASE	interacts_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.65
MOTOR NEURON	expresses	cell_type	0.60
NEURONS	expresses	cell_type	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.60
CORTICOBASAL DEGENERATION	interacts_with	disease	0.60
FUS	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.60
CORTICOBASAL DEGENERATION	causes	disease	0.60
MOTOR NEURON	causes	cell_type	0.60
MAPT	activates	gene	0.60
CORTICOBASAL DEGENERATION	associated_with	disease	0.60
CREUTZFELDT-JAKOB	associated_with	disease	0.60
CORTICOBASAL DEGENERATION	regulates	disease	0.60
AD	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	disease	0.60
DLB	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	disease	0.60
AD	markers	gene	0.60
ALZHEIMER'S DISEASE	markers	disease	0.60
PARKINSON'S DISEASE	regulates	disease	0.60
ASTROCYTES	associated_with	cell_type	0.60
NEURON	associated_with	cell_type	0.60
NEURON	causes	cell_type	0.60
PD	co_discussed	gene	0.60
PD	regulates	gene	0.60
AD	associated_with	gene	0.60
PARKINSON DISEASE	co_discussed	disease	0.60
ALZHEIMER'S DISEASE	expresses	disease	0.60
ALS	associated_with	gene	0.60
AD	regulates	gene	0.60
DLB	regulates	gene	0.60
DLB	co_discussed	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROGRESSIVE SUPRANUCLEAR PALSY in their description or question text

No additional research found