gene

CD8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1116Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CD8 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 614 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD8
Chromosome	2p11.2 (CD8A), 2p11.2 (CD8B)
Protein Family	Immunoglobulin superfamily
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~25-32 kDa (heterodimer)
Pathways	Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cholesterol
UniProt ID	P01732 (CD8A), P10966 (CD8B)
GeneCards	CD8
Human Protein Atlas	CD8
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Arthritis
Known Drugs/Compounds	dimethyl fumarate
Interactions	ACETYL-COA, Actin, AGING, Akt, AKT, ALPHA-SYNUCLEIN
KG Connections	1114 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CD8 — AlphaFold P01732 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CD8(["CD8"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    Als["Als"]
    Inflammation["Inflammation"]
    GENES(["GENES"])
    CANCER(["CANCER"])
    INFLAMMATION(["INFLAMMATION"])
    Lung_Cancer["Lung Cancer"]
    STING(["STING"])
    Checkpoint_Inhibitor["Checkpoint Inhibitor"]
    Immunotherapy["Immunotherapy"]

    CD8 -->|"activates"| Cancer
    CD8 -->|"activates"| Tumor
    CD8 -->|"therapeutic target"| Cancer
    CD8 -->|"activates"| Als
    CD8 -.->|"inhibits"| Cancer
    CD8 -->|"activates"| Inflammation
    GENES -->|"activates"| CD8
    CANCER -->|"activates"| CD8
    CANCER -->|"therapeutic target"| CD8
    INFLAMMATION -->|"activates"| CD8
    CD8 -.->|"inhibits"| Tumor
    CD8 -->|"activates"| Lung_Cancer
    CD8 -->|"activates"| STING
    CD8 -->|"activates"| Checkpoint_Inhibitor
    CD8 -->|"therapeutic target"| Immunotherapy

    style CD8 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (773)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Tumor	inhibits	disease	0.95
T CELLS	interacts_with	cell_type	0.95
Lung Cancer	activates	disease	0.95
T cells	associated_with	cell_type	0.90
Immunotherapy	therapeutic_target	pathway	0.90
STING	activates	gene	0.90
Checkpoint Inhibitor	activates	pathway	0.90
Tumor Microenvironment	activates	pathway	0.90
Immune Checkpoint	activates	pathway	0.90
Als	expressed_in	disease	0.85
Carcinoma	therapeutic_target	disease	0.85
Cancer	regulates	disease	0.85
Tumor	regulates	disease	0.85
Tumor	associated_with	disease	0.85
Carcinoma	activates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Als	therapeutic_target	disease	0.85
Als	inhibits	disease	0.85
oxidative stress response	participates_in	pathway	0.80
Glioblastoma	biomarker_for	disease	0.80
T cells	expressed_in	cell_type	0.80
T CELLS	activates	cell_type	0.80
T cells	activates	cell_type	0.80
MYC	activates	gene	0.80
Immunotherapy	activates	pathway	0.80
Immune Response	inhibits	pathway	0.80
CD4	associated_with	gene	0.80
Apoptosis	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Phagocytosis	activates	pathway	0.80
MICROGLIA	activates	gene	0.80
IFN	activates	gene	0.80
Cancer	expressed_in	disease	0.75
Carcinoma	inhibits	disease	0.75
Carcinoma	expressed_in	disease	0.75
Als	causes	disease	0.75
Als	regulates	disease	0.75
Aging	inhibits	disease	0.75
Inflammation	associated_with	disease	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Aging	activates	disease	0.75
Parkinson	expressed_in	disease	0.75
Inflammation	expressed_in	disease	0.75
Senescence	inhibits	disease	0.75

Incoming (343)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
CANCER	activates	gene	1.00
GENES	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	0.90
Maladaptive Microglia Activation	associated_with	process	0.85
CD19	associated_with	gene	0.80
CCL5	activates	gene	0.80
STING	activates	gene	0.80
CANCER	inhibits	gene	0.80
GENES	associated_with	gene	0.80
PARKINSON'S DISEASE	expressed_in	gene	0.70
GSDME	activates	gene	0.70
TREX1	activates	gene	0.70
CD4	inhibits	gene	0.70
STAT3	activates	gene	0.70
EGFR	activates	gene	0.70
CANCER	expressed_in	gene	0.70
AGING	inhibits	gene	0.70
MHC-I	inhibits	gene	0.70
CANCER	regulates	gene	0.70
PHAGOCYTOSIS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
CYTOKINES	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
cxcl10	activates	protein	0.70
INFLAMMATION	expressed_in	gene	0.70
PARKINSON	expressed_in	gene	0.70
CXCL10	activates	gene	0.70
CD40	activates	gene	0.70
CD4	therapeutic_target	gene	0.70
AUTOPHAGY	activates	gene	0.70
glycogen_metabolism	regulates	pathway	0.64
beta_hydroxybutyrate	regulates	drug	0.64
CXCR3	therapeutic_target	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	activates	gene	0.60
STAR	expressed_in	gene	0.60
MELK	activates	gene	0.60
CIITA	activates	gene	0.60
MAF	inhibits	gene	0.60
ANGPT1	activates	gene	0.60
IRF1	activates	gene	0.60
GFAP	regulates	gene	0.60
CAMK4	therapeutic_target	gene	0.60
RAB7A	regulates	gene	0.60
TLR7	interacts_with	gene	0.60
MTOR	expressed_in	gene	0.60
OPA1	associated_with	gene	0.60
GAIN	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD8+ T-Cell Perforin Pathway as Driver of Neuronal Pyramid L	0.710	Alzheimer's disease, Parkinson's disease	-
Paraneoplastic myelopathies involve CD8+ T cell recognition	0.450	neuroinflammation	What are the specific pathophysiological

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.698

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed contradictory evidence about CD8+ T cell roles in neurodegen

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CD8 in their description or question text

No additional research found

CD8