Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAMK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene page for CAMK4 - calcium/calmodulin-dependent protein kinase involved in transcriptional regulation, synaptic plasticity, and immune function
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| Gene Symbol | CAMK4 |
| Full Name | Calcium/Calmodulin-Dependent Kinase 4 |
| Aliases | Gene page for CAMK4 |
| Chromosome | 5q31.3 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that plays a critical role in linking calcium signaling to gene transcription in neurons and immune cells. |
| Primary Expression | Hippocampus, Cerebellum, Thymus, Testis, T-lymphocytes |
| Subcellular Localization | the postsynaptic density (PSD) and nucleus, with activity-dependent translocation between these compartments [4](https:/ |
| Molecular Weight | 63 kDa |
| Amino Acids | 519 aa |
| Exons | 14 |
| UniProt ID | Q16566 |
| NCBI Gene ID | 814 |
| Ensembl ID | ENSG00000152495 |
| OMIM | 114080 |
| GeneCards | CAMK4 |
| Human Protein Atlas | CAMK4 |
| Associated Diseases | Cancer, Tumor |
| Interactions | AND, ANK3, CANCER, ETV6, GENES, ZBTB20 |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CAMK4["CAMK4"]
Cancer{"Cancer"}
CAMK4 -->|"associated with"| Cancer
Tumor{"Tumor"}
CAMK4 -->|"associated with"| Tumor
CAMK4 -->|"therapeutic target"| Cancer
CAMK4 -->|"therapeutic target"| Tumor
GENES["GENES"]
CAMK4 -->|"activates"| GENES
ZBTB20["ZBTB20"]
CAMK4 -->|"activates"| ZBTB20
CD8["CD8"]
CAMK4 -->|"associated with"| CD8
ANK3["ANK3"]
CAMK4 -->|"activates"| ANK3
SPP1["SPP1"]
CAMK4 -->|"associated with"| SPP1
CAMK4 -->|"therapeutic target"| CD8
ETV6["ETV6"]
CAMK4 -->|"activates"| ETV6
CAMK4 -->|"therapeutic target"| SPP1
SPP1 -->|"associated with"| CAMK4
CD8 -->|"associated with"| CAMK4
ANK3 -->|"activates"| CAMK4
ZBTB20 -->|"activates"| CAMK4
ETV6 -->|"activates"| CAMK4
AND["AND"]
AND -->|"activates"| CAMK4
style CAMK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-db4a006ea647 | provides_data_for | dataset | 1.00 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| CD8 | therapeutic_target | gene | 0.60 |
| SPP1 | therapeutic_target | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ZBTB20 | activates | gene | 0.60 |
| ANK3 | activates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| T Cell | associated_with | cell_type | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| SPP1 | associated_with | gene | 0.60 |
| ETV6 | activates | gene | 0.60 |
| TEX | expressed_in | cell_type | 0.56 |
| T Cell | expressed_in | cell_type | 0.55 |
| CD8 | co_expressed_with | gene | 0.50 |
| SPP1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CAMK4 in their description or question text
No additional research found