gene

CD40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

0Analyses

50Outgoing

11Incoming

0Experiments

0Debates

Summary

CD40 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with AD, ALI, Aging. Connected to 74 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD40
Full Name	Cluster of Differentiation 40
Chromosome	20q12
Protein Family	TNF receptor superfamily
Function	CD40-CD40L signaling is central to immune function
Primary Expression	AD brain by microglia and astrocytes - CD40-CD40L interaction promotes: - Microglial activation - Pro-i
Molecular Weight	48 kDa
Amino Acids	277 aa
Exons	9
Pathways	NF-κB, MAPK pathway, PI3K
GeneCards	CD40
Human Protein Atlas	CD40
Associated Diseases	AD, ALI, Autoimmune, cancer, disease
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, AQP4, CD8, C-FOS
KG Connections	99 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD40 - Cluster of Differentiation 40

gene · 772 words

→

CD40 Protein - Cluster of Differentiation 40

protein · 695 words

→

Pathway Diagram

graph TD
    CD40["CD40"]
    CD40L["CD40L"]
    CD40 -->|"binds"| CD40L
    TRAF2["TRAF2"]
    CD40 -->|"interacts with"| TRAF2
    TRAF3["TRAF3"]
    CD40 -->|"interacts with"| TRAF3
    TRAF5["TRAF5"]
    CD40 -->|"interacts with"| TRAF5
    TRAF6["TRAF6"]
    CD40 -->|"interacts with"| TRAF6
    c_IAP1["c-IAP1"]
    CD40 -->|"interacts with"| c_IAP1
    NF__B(["NF-kappaB"])
    CD40 -->|"activates"| NF__B
    Cancer{"Cancer"}
    CD40 -->|"expressed in"| Cancer
    Autoimmune{"Autoimmune"}
    CD40 -->|"expressed in"| Autoimmune
    Ms{"Ms"}
    CD40 -->|"expressed in"| Ms
    Als{"Als"}
    CD40 -->|"therapeutic target"| Als
    CD40 -->|"therapeutic target"| Autoimmune
    CD40L -->|"binds"| CD40
    AQP4["AQP4"]
    AQP4 -->|"expressed in"| CD40
    CLOCK["CLOCK"]
    CLOCK -->|"regulates"| CD40
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| CD40
    TCR["TCR"]
    TCR -->|"activates"| CD40
    AND["AND"]
    AND -->|"activates"| CD40
    style CD40 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (88)

Target	Relation	Type	Str
CD8	activates	gene	0.70
Als	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Als	regulates	disease	0.65
Stroke	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Tumor	regulates	disease	0.65
Parkinson	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Autoimmune	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
AQP4	expressed_in	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PROINFLAMMATORY CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
TNF	expressed_in	gene	0.60
FOSB	activates	gene	0.60
EGF	interacts_with	gene	0.60
VEGF	interacts_with	gene	0.60
NOTCH1	activates	gene	0.60
CD8	interacts_with	gene	0.60
NOTCH1	interacts_with	gene	0.60
NOTCH1	regulates	gene	0.60
MCL1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
neuroinflammation	interacts_with	disease	0.60
endothelial cells	expressed_in	cell_type	0.60
CCL5	regulates	gene	0.60
DNA	activates	gene	0.60
C-FOS	activates	gene	0.60
Immune Response	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
Raf	regulates	protein	0.60

Incoming (11)

Source	Relation	Type	Str
TNF	regulates	gene	0.60
CD4	expressed_in	gene	0.60
AQP4	activates	entity	0.60
FOS	activates	gene	0.60
ROS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
TCR	activates	gene	0.60
AQP4	expressed_in	gene	0.60
CLOCK	regulates	gene	0.60
AQP4	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD40 in their description or question text

No additional research found