gene 889 words KG: CD8
Contents

CD8 Gene

🧬 Gene Info
Gene SymbolCD8
Chromosome2p11.2 (CD8A), 2p11.2 (CD8B)
Protein FamilyImmunoglobulin superfamily
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~25-32 kDa (heterodimer)
PathwaysAdaptive Immunity, Amyloid, Apoptosis, Autophagy, Cholesterol
UniProt IDP01732 (CD8A), P10966 (CD8B)
GeneCardsCD8
Human Protein AtlasCD8
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Arthritis
Known Drugs/Compoundsdimethyl fumarate
InteractionsACETYL-COA, Actin, AGING, Akt, AKT, ALPHA-SYNUCLEIN
KG Connections1114 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (25)

Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

NPM1 knockout tumor progression study in syngeneic mice
validation · proposed · Score: 0.90
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (7)

ACTB Gene
gene · KG edge: regulates
AKT1 Gene
gene · KG edge: therapeutic_target
ALDH1L1
gene · KG edge: associated_with
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

beta_hydroxybutyrate regulates CD8
glycogen_metabolism regulates CD8
CD8 participates_in PHOSPHOLIPID_METABOLISM
CD8 activates PDGFRB
CD8 activates ANGPT1
NPM1 activates CD8
NLRC5 activates CD8
CD8 activates IRF1
CD8 activates CIITA
CD8 expressed_in STAR

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