gene 1,761 words KG: ent-gene-53dc06f9
Contents

ASCL1 Gene

🧬 Gene Info
Gene SymbolASCL1
Full NameAchaete-Scute Homolog 1
Chromosome12p23.2
Protein TypeTranscription Factor
Functionis a basic helix-loop-helix (bHLH) transcription factor essential for neural development, neurogenesis, and the differentiation of specific neuronal lineages.
Primary Expressionmultiple developmental contexts:
Molecular Weight26.8 kDa
Amino Acids237 aa
UniProt IDP50567
NCBI Gene ID41
Ensembl IDENSG00000139352
OMIM100800
GeneCardsASCL1
Human Protein AtlasASCL1
Canonical E-boxCANNTG (preferred: CAGCTG, CACGTG)
Associated DiseasesCancer, Lung Cancer, Tumor
InteractionsBCL2, Bdnf, BDNF, CANCER, DNA, GBM
KG Connections116 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
Netrin-1 Gradient Restoration
Score: 0.59

Related Analyses (7)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (7)

Bipolar Cells in Visual Processing
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
BCL2 Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (2 edges)

ent-gene-53dc06f9 data_in benchmark_ot_ad_answer_key:ASCL1
benchmark_ot_ad_answer_key:ASCL1 data_in ent-gene-53dc06f9

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