concept

MYCN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

26Outgoing

21Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MYCN
Key Genes/Proteins	AGER, AND, APOPTOSIS, ASCL1, ATRX, CANCER
Related Diseases	Als, ALS, Cancer
Related Pathways	Apoptosis, Epigenetic

Pathway Diagram

graph TD
    MYCN["MYCN"]
    MYCN -->|"inhibited_in"| neuroblastoma_persister_cells["neuroblastoma persister cells"]
    MYCN -->|"activates"| Als["Als"]
    MYCN -->|"activates"| Cancer["Cancer"]
    MYCN -->|"activates"| Tumor["Tumor"]
    MYCN -->|"activates"| ALS["ALS"]
    MYCN -->|"activates"| Apoptosis["Apoptosis"]
    MYCN -->|"activates"| CANCER["CANCER"]
    APOPTOSIS["APOPTOSIS"] -->|"activates"| MYCN
    ONCOGENES["ONCOGENES"] -->|"activates"| MYCN
    IRF2BP2["IRF2BP2"] -->|"activates"| MYCN
    GENES["GENES"] -->|"activates"| MYCN
    AND["AND"] -->|"causes"| MYCN
    PTEN["PTEN"] -->|"target for"| MYCN
    TP53["TP53"] -->|"target for"| MYCN

Outgoing (26)

Target	Relation	Type	Str
neuroblastoma persister cells	inhibited_in	cell_type	0.93
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
GENES	activates	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
P53	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60
NF1	associated_with	gene	0.60
PDGFRA	associated_with	gene	0.60
TP53	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
SETD2	associated_with	gene	0.60
T cells	expressed_in	cell_type	0.60
Apoptosis	activates	pathway	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IRF2BP2	activates	gene	0.60
ONCOGENES	activates	gene	0.60
B Cell	activates	cell_type	0.60
IRF2BP2	causes	gene	0.60
AND	causes	gene	0.60
B Cell	expressed_in	cell_type	0.55

Incoming (21)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	0.60
ONCOGENES	activates	gene	0.60
IRF2BP2	activates	gene	0.60
PTEN	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
EZH2	therapeutic_target	gene	0.60
SYP	therapeutic_target	gene	0.60
ASCL1	regulates	gene	0.60
RB1	therapeutic_target	gene	0.60
SOX2	therapeutic_target	gene	0.60
FOXA2	regulates	gene	0.60
ATRX	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
IFN	activates	gene	0.60
EZH2	activates	gene	0.60
MYC	activates	gene	0.60
GENES	activates	gene	0.60
AND	causes	gene	0.60
IRF2BP2	causes	gene	0.60
AGER	associated_with	gene	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MYCN in their description or question text

No additional research found