gene

WNT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

30Outgoing

19Incoming

0Experiments

0Debates

Summary

Page for WNT1 Gene

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🧬 Gene Info

Gene Symbol	WNT1
Chromosome	12q13.12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	discrete regions of the developing and adult brain:
Molecular Weight	38 kDa
Amino Acids	370 aa
Exons	4
Pathways	Wnt, WNT
UniProt ID	P56746
NCBI Gene ID	7471
Ensembl ID	ENSG00000125084
GeneCards	WNT1
Human Protein Atlas	WNT1
Associated Diseases	neurodegeneration
Known Drugs/Compounds	IPA
Interactions	ADRA2B, AND, ASTROCYTE, CHRM4, CHRNE, CRH
KG Connections	49 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WNT1 — AlphaFold P56746 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WNT1["WNT1"]
    Als["Als"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRIN3B["GRIN3B"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1 -->|"activates"| Als
    WNT1 -->|"activates"| ASTROCYTE
    WNT1 -->|"activates"| CRH
    WNT1 -->|"activates"| WNT
    WNT1 -->|"activates"| ADRA2B
    WNT1 -->|"activates"| IL13
    WNT1 -->|"activates"| CHRNE
    WNT1 -->|"activates"| WNT11
    WNT1 -->|"activates"| GRIN3B
    WNT1 -->|"activates"| TNFRSF1B
    WNT1 -->|"activates"| GABA
    WNT1 -->|"activates"| TNFRSF13C
    WNT1 -->|"activates"| HCRTR1
    WNT1 -->|"activates"| CYTOKINES
    WNT1 -->|"activates"| Wnt
    WNT1 -->|"activates"| Microglia
    WNT1 -->|"activates"| Astrocyte
    CHRM4 -->|"activates"| WNT1
    MYO7A -->|"activates"| WNT1
    GRM2 -->|"activates"| WNT1
    style WNT1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (30)

Target	Relation	Type	Str
STAT3	activates	protein	0.85
Als	activates	disease	0.65
ALS	activates	disease	0.65
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60
MYO7A	activates	gene	0.60
CHRM4	activates	gene	0.60
GRM2	activates	gene	0.60
Rb	activates	protein	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
Cytokine	activates	protein	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CRH	activates	gene	0.60
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
Brainstem	expressed_in	brain_region	0.55
WNT SIGNALING	activates	concept	0.50

Incoming (19)

Source	Relation	Type	Str
IPA	inhibits	compound	0.95
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
CHRM4	activates	gene	0.60
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
CRH	activates	gene	0.60
IL13	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
CHRNE	activates	gene	0.60
ADRA2B	activates	gene	0.60
GRIN3B	activates	gene	0.60
HCRTR1	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
WNT SIGNALING	expressed_in	pathway	0.55
WNT11	activates	gene	0.50
WNT SIGNALING	associated_with	pathway	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT1 in their description or question text

No additional research found

WNT1

Understanding Entity Pages

Summary

Wiki Pages (6)

WNT1 Gene

WNT10A Gene

WNT11 Gene

WNT1 Protein

WNT10B Gene

WNT16 Gene