protein 757 words KG: VGF
Contents

VGF Nerve Growth Factor

🔬 Protein Info
Gene SymbolVGF
Chromosome7q22.1
Primary Expressionneurons of the central and peripheral nervous systems
Molecular Weight~68 kDa
Amino Acids617 aa
PathwaysMAPK pathway, PI3K, AMPK pathway
UniProt IDQ9UK23
NCBI Gene ID5139
GeneCardsVGF
Human Protein AtlasVGF
Neuronal developmentPromotes neuronal survival and differentiation
Synaptic plasticityRegulates synaptic function and memory formation
Energy homeostasisControls appetite and metabolism
Disease associationsAlzheimer's disease, depression, cachexia, neurodegenerative disorders
Protein Length617 amino acids
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsAMYLOID, BDNF, CST3, CTSB, CTSD, CTSS
KG Connections116 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
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neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
GFAP (Redirect)
redirect · KG edge: expressed_in
CD44 - Cell Surface Glycoprotein
gene · KG edge: associated_with
CST3 Gene - Cystatin C
gene · KG edge: inhibits
CTSS — Cathepsin S
gene · KG edge: inhibits

Knowledge Graph (12 edges)

VGF associated_with NTN1
VGF associated_with GPNMB
VGF associated_with NPTX2
GPNMB associated_with VGF
NPTX2 associated_with VGF
NTN1 associated_with VGF
HSPA1A activates VGF
VGF activates HDAC1
PI3K expressed_in VGF
VGF regulates AKT

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