gene

CST3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CST3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

26Outgoing

16Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	CST3
Full Name	Cystatin C
Chromosome	20p11.21
Function	Cysteine protease inhibition
Molecular Weight	13 kDa
Amino Acids	120 aa
UniProt ID	P01034
NCBI Gene ID	1471
Ensembl ID	ENSG00000141540
OMIM	123400
GeneCards	CST3
Human Protein Atlas	CST3
Associated Diseases	ALS, Diabetes, Hypertension
Interactions	Amyloid, AMYLOID, CTSB, CTSD, CTSS, NPTX1
KG Connections	42 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CST3 — AlphaFold P01034 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CST3["CST3"]
    Alzheimer["Alzheimer"]
    CST3 -->|"regulates"| Alzheimer
    Als["Als"]
    CST3 -->|"activates"| Als
    Diabetes["Diabetes"]
    CST3 -->|"activates"| Diabetes
    Hypertension["Hypertension"]
    CST3 -->|"causes"| Hypertension
    ALS["ALS"]
    CST3 -->|"causes"| ALS
    Diabetes["Diabetes"]
    CST3 -->|"causes"| Diabetes
    APBB1["APBB1"]
    CST3 -->|"regulates"| APBB1
    FN1["FN1"]
    CST3 -->|"regulates"| FN1
    C1QA["C1QA"]
    CST3 -->|"regulates"| C1QA
    CTSS["CTSS"]
    CST3 -->|"activates"| CTSS
    NPTX1["NPTX1"]
    CST3 -->|"inhibits"| NPTX1
    SERPINA3["SERPINA3"]
    CST3 -->|"inhibits"| SERPINA3
    NRXN2["NRXN2"]
    CST3 -->|"inhibits"| NRXN2
    VGF["VGF"]
    CST3 -->|"inhibits"| VGF
    SYNAPSE["SYNAPSE"]
    CST3 -->|"inhibits"| SYNAPSE
    CTSB["CTSB"]
    CST3 -->|"activates"| CTSB
    CTSD["CTSD"]
    CST3 -->|"activates"| CTSD
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    CST3 -->|"causes"| DIABETES_MELLITUS
    Amyloid["Amyloid"]
    CST3 -->|"causes"| Amyloid
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| CST3
    APP["APP"]
    APP -->|"regulates"| CST3
    CLU["CLU"]
    CLU -->|"regulates"| CST3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| CST3
    GENES["GENES"]
    GENES -->|"regulates"| CST3
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"causes"| CST3
    C1QA["C1QA"]
    C1QA -->|"regulates"| CST3
    APBB1["APBB1"]
    APBB1 -->|"regulates"| CST3
    AND["AND"]
    AND -->|"causes"| CST3
    FN1["FN1"]
    FN1 -->|"regulates"| CST3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"causes"| CST3

Outgoing (26)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Hypertension	causes	disease	0.65
ALS	causes	disease	0.65
Diabetes	causes	disease	0.65
Diabetes	activates	disease	0.65
Hypertension	activates	disease	0.65
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
APP	regulates	gene	0.60
CLU	regulates	gene	0.60
SCA3	associated_with	gene	0.60
FN1	regulates	gene	0.60
SYNAPSE	inhibits	gene	0.60
DIABETES MELLITUS	causes	gene	0.60
Amyloid	causes	pathway	0.60
Amyloid	activates	protein	0.60
C1QA	regulates	gene	0.60
CTSS	activates	gene	0.60
NPTX1	inhibits	gene	0.60
SERPINA3	inhibits	gene	0.60
NRXN2	inhibits	gene	0.60
VGF	inhibits	gene	0.60
APBB1	regulates	gene	0.60
Hippocampus	expressed_in	brain_region	0.55
ALZHEIMER	regulates	gene	0.50

Incoming (16)

Source	Relation	Type	Str
GENES	regulates	gene	0.60
ALZHEIMER DISEASE	causes	gene	0.60
AND	causes	gene	0.60
FN1	regulates	gene	0.60
AMYLOID	causes	gene	0.60
C1QA	regulates	gene	0.60
APBB1	regulates	gene	0.60
APP	regulates	gene	0.60
CLU	regulates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	co_discussed	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	co_discussed	gene	0.60
CLU	co_discussed	gene	0.60
apbb1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CST3 in their description or question text

No additional research found