gene

UCP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UCP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

46Outgoing

50Incoming

0Experiments

0Debates

Summary

UCP2 is a mitochondrial uncoupling protein that regulates proton leak, ROS production, and energy metabolism. It has complex roles in neurodegeneration with both protective and potentially detrimental effects in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	UCP2
Full Name	Uncoupling Protein 2
Chromosome	11q13.4
Protein Type	Protein
Function	UCP2 is a mitochondrial anion carrier protein that uncouples oxidative phosphorylation:
Amino Acids	309 aa
Pathways	AMPK
UniProt ID	Search UniProt
GeneCards	UCP2
Human Protein Atlas	UCP2
AMP-activated protein kinase (AMPK)	Energy deficit activates AMPK, promoting UCP2 expression.
Sirtuins (SIRT1/SIRT2)	NAD+-dependent deacetylases regulate UCP2 under metabolic stress conditions.
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	AGING, AIM2, AMPK, AND, APOPTOSIS, ASC
KG Connections	104 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: UCP2 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UCP2 — Uncoupling Protein 2

gene · 1820 words

→

Uncoupling Protein 2 (UCP2)

protein · 617 words

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Pathway Diagram

graph TD
    UCP2["UCP2"]
    Als{"Als"}
    UCP2 -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    UCP2 -->|"regulates"| Cardiac
    Ms{"Ms"}
    UCP2 -->|"regulates"| Ms
    Ischemia{"Ischemia"}
    UCP2 -->|"regulates"| Ischemia
    Obesity{"Obesity"}
    UCP2 -->|"activates"| Obesity
    Inflammation{"Inflammation"}
    UCP2 -->|"activates"| Inflammation
    PINK1["PINK1"]
    UCP2 -->|"associated with"| PINK1
    Mitophagy(["Mitophagy"])
    UCP2 -->|"associated with"| Mitophagy
    INFLAMMATION["INFLAMMATION"]
    UCP2 -->|"activates"| INFLAMMATION
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    UCP2 -->|"activates"| MICROGLIA_ACTIVATION
    Immune_Response(["Immune Response"])
    UCP2 -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    UCP2 -->|"implicated in"| neurodegeneration
    LC3B["LC3B"]
    LC3B -->|"protects against"| UCP2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"associated with"| UCP2
    NRG1["NRG1"]
    NRG1 -->|"regulates"| UCP2
    POMC["POMC"]
    POMC -->|"activates"| UCP2
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| UCP2
    AND["AND"]
    AND -->|"activates"| UCP2
    style UCP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Als	inhibits	disease	0.75
Obesity	activates	disease	0.75
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Immune Response	activates	pathway	0.70
Neuroinflammation	activates	disease	0.65
Glaucoma	inhibits	disease	0.65
Fatty Liver	activates	disease	0.65
Diabetes	activates	disease	0.65
Aging	activates	disease	0.65
ALS	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Ms	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Melanoma	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Retinopathy	activates	disease	0.65
LC3B	protects_against	gene	0.60
ATP	inhibits	gene	0.60
Nlrp3 Inflammasome	inhibits	pathway	0.60
ROS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Endothelial	activates	cell_type	0.60
PINK1	associated_with	gene	0.60
Cytokine	activates	protein	0.60
NEUROINFLAMMATION	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Glycolysis	activates	pathway	0.60
PARKIN	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
ASC	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
VDAC1	associated_with	gene	0.60
Autophagy	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60
Inflammasome	inhibits	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Mitophagy	associated_with	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
AIM2	inhibits	gene	0.60

Incoming (58)

Source	Relation	Type	Str
MICROGLIA ACTIVATION	activates	gene	0.60
AGING	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
POMC	activates	gene	0.60
STAT3	inhibits	gene	0.60
NAD	activates	gene	0.60
NADH	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
PINK1	regulates	gene	0.60
PARP1	activates	gene	0.60
POLG	activates	gene	0.60
DRP1	regulates	gene	0.60
LC3B	protects_against	gene	0.60
MITOPHAGY	associated_with	gene	0.60
ROS	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ASC	inhibits	gene	0.60
AIM2	inhibits	gene	0.60
NLRC4	inhibits	gene	0.60
SIRT2	inhibits	gene	0.60
VEGF	activates	gene	0.60
MMP9	activates	gene	0.60
EGR1	therapeutic_target	gene	0.60
RAGE	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
GPR109A	inhibits	gene	0.60
FUNDC1	associated_with	gene	0.60
MCU	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
GENES	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DNA	activates	gene	0.60
GLUT1	activates	gene	0.60
ATP	activates	gene	0.60
FTO	interacts_with	gene	0.60
AND	inhibits	gene	0.60
NRG1	regulates	gene	0.60
PPAR	activates	gene	0.60
SIRT1	activates	gene	0.60
OVERVIEW	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ATP	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UCP2 in their description or question text

No additional research found