gene 815 words KG: TUBB3
Contents

TUBB3 Gene

🧬 Gene Info
Gene SymbolTUBB3
Full NameTubulin Beta 3 Class III
Chromosome16q24.3
Protein FamilyTubulin family
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionTUBB3 performs essential neuronal functions:
Mechanism of ActionSmall molecule stabilizers of microtubule structure or assembly
DruggabilityMedium (0.49)
Clinical StageApproved
Molecular Weight50 kDa
Amino Acids450 aa
PathwaysAkt, Autophagy, Cell Cycle, Pi3K, Proteasome
UniProt IDG3V3R4
Ensembl IDENSG00000198363
GeneCardsTUBB3
Human Protein AtlasTUBB3
Associated DiseasesAlzheimer, Alzheimer's disease, Bone Metastasis, Huntington, Huntington's disease, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACTB, Actin, ALZHEIMER, ALZHEIMER DISEASE, AND, APOPTOSIS
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesQuantum Coherence Disruption in Cellular Communica
KG Connections414 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Quantum Coherence Disruption in Cellular Communication
Score: 0.63
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73

Related Analyses (7)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACTB Gene
gene · KG edge: activates
ar
gene · KG edge: activates
ATG14 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

BMAL1 co_discussed TUBB3
CNO co_discussed TUBB3
TUBB3 co_discussed CLOCK
TUBB3 co_discussed PLIN2
TUBB3 co_discussed PIEZO1
TUBB3 co_discussed GABRA1
TUBB3 co_discussed G3BP1
JUN therapeutic_target TUBB3
TUBB3 inhibits SRC
ACTB regulates TUBB3

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