gene

XPO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

26Outgoing

25Incoming

0Experiments

0Debates

Summary

XPO1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, implicated in. Associated with ALS, Als, Cancer. Connected to 18 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	XPO1
Full Name	Exportin 1 (CRM1)
Chromosome	2p15
Protein Type	Receptor
Function	XPO1/CRM1 is a member of the karyopherin family
Primary Expression	cancer and neurodegenerative diseases
UniProt ID	O14980
NCBI Gene ID	7514
Ensembl ID	ENSG00000100401
GeneCards	XPO1
Human Protein Atlas	XPO1
Nuclear export	exports proteins with nuclear export signals (NES)
RNA export	mediates export of various RNA species
Protein shuttling	regulates localization of transcription factors
Stress response	exports stress-related proteins
Associated Diseases	neurodegeneration
Interactions	ALS, AND, CANCER, CDK4, CRBN, DNA
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: XPO1 — AlphaFold O14980 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

XPO1 Gene

gene · 776 words

→

XPO1/CRM1 Protein

protein · 1116 words

→

Pathway Diagram

graph TD
    XPO1["XPO1"]
    Leukemia{"Leukemia"}
    XPO1 -->|"expressed in"| Leukemia
    Ms{"Ms"}
    XPO1 -->|"expressed in"| Ms
    Als{"Als"}
    XPO1 -->|"expressed in"| Als
    ALS{"ALS"}
    XPO1 -->|"expressed in"| ALS
    NPM1["NPM1"]
    XPO1 -->|"inhibits"| NPM1
    GENES["GENES"]
    XPO1 -->|"expressed in"| GENES
    neurodegeneration["neurodegeneration"]
    XPO1 -->|"implicated in"| neurodegeneration
    NPM1 -->|"inhibits"| XPO1
    GENES -->|"expressed in"| XPO1
    AND["AND"]
    AND -->|"inhibits"| XPO1
    style XPO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:XPO1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
TP53	reduces	protein	0.85
Acute Myeloid Leukemia	therapeutic_target	disease	0.80
NPM1-mutated Acute Myeloid Leukemia	therapeutic_target	disease	0.75
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Leukemia	expressed_in	disease	0.65
Senescence	inhibits	disease	0.65
Als	inhibits	disease	0.65
Immune Response	inhibits	pathway	0.60
P53	inhibits	gene	0.60
autophagy pathway	participates_in	pathway	0.60
GENES	expressed_in	gene	0.60
AND	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
DNA	inhibits	gene	0.60
Differentiation	inhibits	pathway	0.60
NPM1	inhibits	gene	0.60
MYC	inhibits	gene	0.60
senescence	participates_in	pathway	0.60
neurodegeneration	inhibits	disease	0.60
neurodegeneration	activates	disease	0.60
disease	inhibits	disease	0.50

Incoming (25)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:XPO1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
DDX3X	associated_with	gene	0.60
KMT2A	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
TREH	associated_with	gene	0.60
CDK4	activates	gene	0.60
RB1	activates	gene	0.60
NPM1	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
ALS	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
RB1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
TFEB	activates	gene	0.60
MLL	inhibits	gene	0.60
CAMK2D	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NCOR1	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
KRAS	inhibits	gene	0.60
AND	inhibits	gene	0.60
CRBN	activates	gene	0.60
CANCER	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XPO1 in their description or question text

No additional research found