gene 903 words KG: TLR9
Contents

TLR9 — Toll-Like Receptor 9

🧬 Gene Info
Gene SymbolTLR9
Full NameToll-Like Receptor 9
Chromosome3p21.3
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmicroglia, astrocytes, and neurons, where it plays a critical role in innate immune responses to pathogen-a
PathwaysNF-κB, MAPK pathway
OMIM605203
GeneCardsTLR9
Human Protein AtlasTLR9
Associated DiseasesALS, Carcinoma, Cirrhosis, Cystic Fibrosis, Fibrosis, Hepatitis
InteractionsAIM2, AMPK, APOE, APOPTOSIS, CD68, Cytokine
KG Connections206 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

See Also (12)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
BMAL1 (ARNTL) Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

TLR9 regulates NET
TLR9 activates MYD88
TLR9 activates TLR4
MYD88 activates TLR9
TLR4 activates TLR9
PI3K expressed_in TLR9
SRC activates TLR9
APOE activates TLR9
P38 activates TLR9
GSDMD activates TLR9

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