gene 1,533 words KG: TLR8
Contents

TLR8 Gene

🧬 Gene Info
Gene SymbolTLR8
Full NameToll-Like Receptor 8
ChromosomeXp22.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmyeloid cells and recognizes single-stranded RNA (ssRNA) from viruses as well as synthetic antiviral compounds
Molecular Weight110 kDa
Amino Acids200 aa
PathwaysMAPK
UniProt ID[Q9NYK5](https://www.uniprot.org/uniprot/Q9NYK5)
Ensembl IDENSG00000101916
OMIM300366
GeneCardsTLR8
Human Protein AtlasTLR8
Leucine-rich repeat (LRR) domainConsists of 25 LRR motifs that form the ligand-binding region
Associated DiseasesMs
InteractionsIL-6, INFLAMMATION, LIPOPHAGY, MTOR, RAB7A, TLR
KG Connections19 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Microbial Inflammasome Priming Prevention
Score: 0.65
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
TNF (Redirect)
redirect · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
MTOR Gene
gene · KG edge: activates
RAB7A — RAB7A, Member RAS Oncogene Family
gene · KG edge: activates

Knowledge Graph (12 edges)

MTOR activates TLR8
RAB7A activates TLR8
TNF activates TLR8
TLR7 activates TLR8
TLR8 activates TLR9
TLR8 activates TLR3
TLR8 inhibits INFLAMMATION
TLR8 inhibits LIPOPHAGY
TLR8 inhibits Ms
TLR8 inhibits Inflammation

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