gene

PLG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

17Outgoing

20Incoming

0Experiments

0Debates

Summary

Plasminogen is a zymogen of plasmin, a serine protease involved in fibrinolysis, extracellular matrix remodeling, and neuronal plasticity. It plays critical roles in synaptic plasticity, neuroinflammation, and blood-brain barrier regulation, with implications for Alzheimer's disease, ALS, and stroke.

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🧬 Gene Info

Gene Symbol	PLG
Full Name	Plasminogen
Chromosome	6q26
Function	tPA-mediated activation: Tissue plasminogen activator (tPA) activates plasminogen preferentially in the presence of fibrin, making it important for clot-specific fibrinolysis.
Primary Expression	neurons and can be released in response to neuronal activity
Amino Acids	810 aa
UniProt ID	[P00747](https://www.uniprot.org/uniprot/P00747)
Ensembl ID	ENSG00000122194
GeneCards	PLG
Human Protein Atlas	PLG
PAI-1 (SERPINE1)	Primary inhibitor of tPA and uPA
PAI-2 (SERPINE2)	Alternative inhibitor expressed in brain
Alpha-2 antiplasmin	Direct inhibitor of plasmin
Associated Diseases	Als, Inflammation, Ms
Interactions	NFKB1, TGFB1
KG Connections	37 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLG — Plasminogen

gene · 2063 words

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Pathway Diagram

graph TD
    PLG["PLG"]
    Als{"Als"}
    PLG -->|"associated with"| Als
    Ms{"Ms"}
    PLG -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    PLG -->|"associated with"| Inflammation
    Ferroptosis(["Ferroptosis"])
    PLG -->|"associated with"| Ferroptosis
    Complement(["Complement"])
    PLG -->|"associated with"| Complement
    neurodegeneration["neurodegeneration"]
    PLG -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"associated with"| PLG
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| PLG
    INFLAMMATION_RELATED_GENES["INFLAMMATION-RELATED GENES"]
    INFLAMMATION_RELATED_GENES -->|"associated with"| PLG
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"associated with"| PLG
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"associated with"| PLG
    EGF["EGF"]
    EGF -->|"associated with"| PLG
    NR4A1["NR4A1"]
    NR4A1 -->|"associated with"| PLG
    style PLG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
TGFB1	activates	protein	0.85
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ischemia	contributes_to	disease	0.65
Cancer	inhibits	disease	0.65
NFKB1	inhibits	gene	0.60
IL30	expressed_in	gene	0.60
Ferroptosis	associated_with	pathway	0.60
GENES	associated_with	gene	0.60
NEURON	contributes_to	gene	0.60
Immune Response	contributes_to	pathway	0.60
Complement	associated_with	pathway	0.60
CASP3	associated_with	gene	0.60
EGF	associated_with	gene	0.60
PTEN	expressed_in	gene	0.60
EFNB2	expressed_in	gene	0.60

Incoming (20)

Source	Relation	Type	Str
EGF	expressed_in	gene	0.60
VEGFA	expressed_in	gene	0.60
ANG	expressed_in	gene	0.60
ACTB	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CD44	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
HGF	expressed_in	gene	0.60
CCL2	expressed_in	gene	0.60
CDH1	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
EGF	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
INFLAMMATION-RELATED GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
COMPLEMENT	contributes_to	gene	0.60
FN1	associated_with	gene	0.60
AND	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLG in their description or question text

No additional research found