gene

ahsa1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ahsa1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	AHSA1
Protein Type	Chaperone
Function	AHSA1 (Activator of Hsp90 ATPase 1), also known as Hsp90 co-chaperone AHA1, is a key co-chaperone that stimulates the ATPase activity of Hsp90.
Primary Expression	Purkinje cells
Molecular Weight	38 kDa
Amino Acids	338 aa
Ensembl ID	ENSG00000100526
GeneCards	AHSA1
Human Protein Atlas	AHSA1
Hsp90 ATPase activation	Stimulates Hsp90 ATP hydrolysis, accelerating the chaperone cycle
Client protein loading	Facilitates proper folding of Hsp90 client proteins
Chaperone complex assembly	Part of the Hsp90 co-chaperone network
Cellular stress response	Modulates cellular responses to proteotoxic stress
Signal transduction	Regulates signaling pathways through client protein maturation
Associated Diseases	Alzheimer's Disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AHSA1

gene · 755 words

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Pathway Diagram

flowchart TD
    AHSA1["AHSA1"] -->|"activates"| EGFR["EGFR"]
    AHSA1["AHSA1"] -->|"activates"| HSP90AA1["HSP90AA1"]
    AHSA1["AHSA1"] -->|"activates"| cancer["cancer"]
    AHSA1["AHSA1"] -->|"activates"| TGFB1["TGFB1"]
    AHSA1["AHSA1"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    style AHSA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EGFR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style HSP90AA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style TGFB1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AHSA1	data_in	dataset_row	0.00
EGFR	activates	gene	0.60
HSP90AA1	activates	gene	0.60
cancer	activates	disease	0.60
TGFB1	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AHSA1	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ahsa1 in their description or question text

No additional research found