| Gene Symbol | STIP1 |
| Full Name | STIP1 / HOP |
| Aliases | STIP1PROTEIN |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 62.5 kDa |
| Amino Acids | 548 aa |
| Pathways | Apoptosis, Chaperone, Tdp-43, autophagy pathway, oxidative stress response |
| UniProt ID | Q9YLS8 |
| GeneCards | STIP1 |
| Human Protein Atlas | STIP1 |
| Hsp70-Hsp90 bridge | Simultaneous binding to both chaperones |
| Client protein transfer | Facilitates hand-off from Hsp70 to Hsp90 |
| Hop-mediated folding | Coordinates folding of nascent and stressed proteins |
| Complex assembly | Helps assemble multi-protein signaling complexes [@johnson1998] |
| Associated Diseases | Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | amyotrophic lateral sclerosis, AND, APOPTOSIS, AQP4, AQUAPORIN-4, AR |
| KG Connections | 193 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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