gene

GNAI2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

18Outgoing

27Incoming

0Experiments

0Debates

Summary

GNAI2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with Als, Cardiovascular, Lymphoma. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GNAI2
Full Name	G Protein Subunit Alpha I2
Chromosome	3p21.31
Function	Gαi2 is an inhibitory G protein that mediates signaling from various G protein-coupled receptors (GPCRs):
Primary Expression	the nervous system and plays crucial roles in neuronal signal transduction, synaptic plasticity, and cellular homeostasis[@gnai]
Pathways	PI3K
UniProt ID	[P04899](https://www.uniprot.org/uniprot/P04899)
Ensembl ID	ENSG00000128283
GeneCards	GNAI2
Human Protein Atlas	GNAI2
GTPase domain	Contains the nucleotide-binding pocket and hydrolyzes GTP
Switch regions I-III	Conformational changes enable effector interactions
N-terminal helix	Mediates interaction with Gβγ dimer and membrane association
Associated Diseases	neurodegeneration
Interactions	AKT, AKT1, AND, APOPTOSIS, AQP4, AQUAPORIN-4
KG Connections	45 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GNAI2 Gene

gene · 783 words

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Pathway Diagram

graph TD
    GNAI2["GNAI2"]
    Lymphoma{"Lymphoma"}
    GNAI2 -->|"activates"| Lymphoma
    Als{"Als"}
    GNAI2 -->|"activates"| Als
    Ms{"Ms"}
    GNAI2 -->|"activates"| Ms
    Cardiovascular{"Cardiovascular"}
    GNAI2 -->|"expressed in"| Cardiovascular
    STIP1["STIP1"]
    GNAI2 -->|"activates"| STIP1
    APOPTOSIS["APOPTOSIS"]
    GNAI2 -->|"activates"| APOPTOSIS
    KEAP1["KEAP1"]
    GNAI2 -->|"activates"| KEAP1
    HO_1["HO-1"]
    GNAI2 -->|"activates"| HO_1
    NRF2["NRF2"]
    GNAI2 -->|"activates"| NRF2
    Apoptosis(["Apoptosis"])
    GNAI2 -->|"activates"| Apoptosis
    NOD2["NOD2"]
    GNAI2 -->|"interacts with"| NOD2
    GNAS["GNAS"]
    GNAI2 -->|"interacts with"| GNAS
    BCL2["BCL2"]
    BCL2 -->|"activates"| GNAI2
    AQP4["AQP4"]
    AQP4 -->|"activates"| GNAI2
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| GNAI2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| GNAI2
    AKT["AKT"]
    AKT -->|"interacts with"| GNAI2
    GNB1["GNB1"]
    GNB1 -->|"interacts with"| GNAI2
    AMPD2["AMPD2"]
    AMPD2 -->|"expressed in"| GNAI2
    ATG5["ATG5"]
    ATG5 -->|"interacts with"| GNAI2
    MAVS["MAVS"]
    MAVS -->|"interacts with"| GNAI2
    TBK1["TBK1"]
    TBK1 -->|"interacts with"| GNAI2
    CLCN7["CLCN7"]
    CLCN7 -->|"expressed in"| GNAI2
    RIPK2["RIPK2"]
    RIPK2 -->|"interacts with"| GNAI2
    style GNAI2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
GNAI3	downregulates	gene	0.70
GNAI1	downregulates	gene	0.70
Lymphoma	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
KEAP1	activates	gene	0.60
NRF2	activates	gene	0.60
STIP1	activates	gene	0.60
Autophagy	interacts_with	pathway	0.60
Wnt	expressed_in	pathway	0.60
Akt	interacts_with	pathway	0.60
NOD2	interacts_with	gene	0.60
Apoptosis	activates	pathway	0.60
GNAS	interacts_with	gene	0.60
GNAI3	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
HO-1	activates	gene	0.60

Incoming (27)

Source	Relation	Type	Str
BCL2	activates	gene	0.60
AQP4	activates	gene	0.60
AND	activates	gene	0.60
KEAP1	activates	gene	0.60
NRF2	activates	gene	0.60
STIP1	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
GNB1	interacts_with	gene	0.60
AMPD2	expressed_in	gene	0.60
ATG5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
CLCN7	expressed_in	gene	0.60
RIPK2	interacts_with	gene	0.60
IFIH1	interacts_with	gene	0.60
GNAI1	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
GNG2	interacts_with	gene	0.60
WDR81	expressed_in	gene	0.60
GNPTG	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
AQUAPORIN-4	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
HO-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNAI2 in their description or question text

No additional research found