gene 1,441 words KG: SPHK1
Contents

SPHK1 — Sphingosine Kinase 1

🧬 Gene Info
Gene SymbolSPHK1
Full NameSphingosine Kinase 1
Chromosome17q25.1
Protein TypeKinase
Function### Sphingolipid Rheostat
Primary ExpressionHippocampus, Cortex, Cerebellum, White matter (widespread)
Molecular Weight42.5 kDa
Exons6
PathwaysNF-κB
UniProt IDQ9NYA1
NCBI Gene ID8877
Ensembl IDENSG00000176884
OMIM603730
GeneCardsSPHK1
Human Protein AtlasSPHK1
Associated DiseasesAls, Atherosclerosis, Cardiac, Cardiovascular, Fibrosis, Heart Failure
Known Drugs/Compoundsrapamycin
InteractionsActin, ALS, ALS-CAUSING MUTATIONS, ASTROCYTE, ASTROCYTES, ATG
KG Connections211 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Purinergic Signaling Polarization Control
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Lysosomal Membrane Repair Enhancement
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: implicated_in
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

SPHK1 activates TARDBP
SPHK1 activates PINK1
SPHK1 activates LC3
SPHK1 activates MTOR
SPHK1 activates PTEN
SPHK1 activates VCP
SPHK1 activates TBK1
SPHK1 activates CHMP2B
SPHK1 activates OVERVIEW
SPHK1 activates VALOSIN

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