Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ganglioside Rebalancing Therapy | 0.690 | neurodegeneration | Lipid raft composition changes in synapt |
| Ganglioside-rich extracellular vesicles preserve alpha-synuc | 0.582 | neurodegeneration | Which specific CSF molecular components |
| GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ | 0.465 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Genetic variants in ganglioside synthesis enzymes associate with Alzheimer's dis [PMID:synthetic_29] | Unknown | Nat Genet | 2024 | 0 |
| CSF ganglioside ratios predict Alzheimer's disease progression and correlate wit [PMID:synthetic_27] | Unknown | JAMA Neurol | 2023 | 0 |
| Small-molecule modulation of ganglioside synthesis normalizes brain lipid compos [PMID:synthetic_26] | Unknown | Nat Neurosci | 2023 | 0 |
| Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect [PMID:35168327] | ["Wang D", "Zhang T", "Maduni\u0107 K", | Journal of proteome research | 2022 | 0 |
| Brain ganglioside composition is dysregulated in Alzheimer's disease with GM1 de [PMID:synthetic_24] | Unknown | Ann Neurol | 2022 | 0 |
| GM1 enhances BDNF-TrkB signaling and neuroprotection via lipid raft organization [PMID:synthetic_28] | Unknown | Mol Psychiatry | 2022 | 0 |
| Ganglioside composition varies widely across brain regions and cell types [PMID:synthetic_32] | Unknown | J Lipid Res | 2021 | 0 |
| Exogenous GM1 administration improves cognition and reduces pathology in APP/PS1 [PMID:synthetic_25] | Unknown | Neurobiol Aging | 2020 | 0 |
| Exogenous GM1 shows limited CNS bioavailability in clinical trials for Parkinson [PMID:synthetic_30] | Unknown | Mov Disord | 2019 | 0 |
| Ganglioside synthesis inhibitors cause peripheral neuropathy in Gaucher disease [PMID:synthetic_31] | Unknown | Ann Neurol | 2018 | 0 |
| Dynamism in gene expression across multiple studies. [PMID:19920211] | ["Morgan A", "Dudley J", "Deshpande T", | Physiological genomics | 2010 | 0 |
| Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricu [PMID:16505173] | ["Pilichou K", "Nava A", "Basso C", "Bef | Circulation | 2006 | 0 |
| Epidermal growth factor receptor as a therapeutic target in human thyroid carcin [PMID:16822827] | ["Mitsiades C", "Kotoula V", "Poulaki V" | The Journal of clinical endocr | 2006 | 0 |
| Re: Use of an Amplatz Goose Neck Snare as a Target for Collateral Neck Vein Dial [PMID:11585895] | Funaki B; Zaleski G X | Journal of Vascular and Interv | 2001 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SIDE in their description or question text
No additional research found