concept

FDX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FDX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FDX1
Key Genes/Proteins	Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS
Related Diseases	Als, ALS, Alzheimer
Related Pathways	Apoptosis, apoptosis pathway, Autophagy

Pathway Diagram

graph TD
    FDX1["FDX1"]
    FDX1 -->|"regulates"| mitophagy["mitophagy"]
    FDX1 -->|"downregulates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    FDX1 -->|"inhibits"| HCC_Cell_Proliferation["HCC Cell Proliferation"]
    FDX1 -->|"inhibits"| HCC_Cell_Invasion["HCC Cell Invasion"]
    FDX1 -->|"inhibits"| ROS["ROS"]
    FDX1 -.protects against.-> hepatocellular_carcinoma["hepatocellular carcinoma"]
    FDX1 -->|"inhibits"| PI3K_AKT["PI3K/AKT"]
    MITOPHAGY["MITOPHAGY"] -->|"activates"| FDX1
    DLAT["DLAT"] -->|"activates"| FDX1
    AKT["AKT"] -->|"activates"| FDX1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| FDX1
    LC3["LC3"] -->|"activates"| FDX1
    GFP["GFP"] -->|"activates"| FDX1
    ROS -->|"activates"| FDX1
    RNA["RNA"] -->|"activates"| FDX1

Outgoing (57)

Target	Relation	Type	Str
Hepatocellular Carcinoma	downregulates	disease	0.95
mitophagy	regulates	process	0.95
HCC Cell Invasion	inhibits	phenotype	0.92
HCC Cell Proliferation	inhibits	phenotype	0.92
hepatocellular carcinoma	protects_against	disease	0.90
ROS	inhibits	phenotype	0.90
ferroptosis	mediates	process	0.90
ROS production	induces	process	0.90
hepatocellular carcinoma	biomarker_for	disease	0.88
Metabolic Reprogramming	regulates	process	0.85
PI3K/AKT	inhibits	pathway	0.85
PI3K	activates	pathway	0.80
Ferroptosis	involved_in	process	0.80
Tumor	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Als	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
SYP	inhibits	gene	0.60
BAX	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
CREB	inhibits	gene	0.60
neurons	expressed_in	cell_type	0.60
ALZHEIMER	inhibits	gene	0.60
Synaptic Plasticity	inhibits	pathway	0.60
Apoptosis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
BDNF	inhibits	gene	0.60
HSP70	activates	gene	0.60
Mitophagy	activates	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
Pi3K/Akt	activates	pathway	0.60
ROS	activates	gene	0.60
Autophagy	associated_with	pathway	0.60
RNA	activates	gene	0.60
LC3	activates	gene	0.60
AND	activates	gene	0.60
Akt	activates	protein	0.60
App	activates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Bdnf	inhibits	protein	0.60
Rb	inhibits	protein	0.60
CD4	expressed_in	gene	0.60

Incoming (25)

Source	Relation	Type	Str
Copper	upregulates	compound	0.85
BAX	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
CREB	inhibits	gene	0.60
SYP	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
HSP70	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
LC3	activates	gene	0.60
GFP	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ROS	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
ATP7A	activates	gene	0.60
DLAT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FDX1 in their description or question text

No additional research found