Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGC1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PGC1Α | data_in | dataset_row | 0.00 |
| h-var-5c4b90eeeb | targeted_by | hypothesis | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | entity | 0.95 |
| ALZHEIMER'S DISEASE | therapeutic_target | entity | 0.95 |
| MITOCHONDRIAL BIOGENESIS | regulates | entity | 0.95 |
| BACE1 | regulates | entity | 0.95 |
| NEUROINFLAMMATION | regulates | entity | 0.90 |
| ROS | regulates | entity | 0.90 |
| NEURODEGENERATION | protects_against | entity | 0.90 |
| Alzheimer's disease | implicated_in | disease | 0.80 |
| MITOCHONDRIAL_FUNCTION | activates | phenotype | 0.72 |
| mitochondrial gene transcription | regulates | process | 0.70 |
| MT-CO2 | regulates | gene | 0.70 |
| MT-ATP6 | regulates | gene | 0.70 |
| MT-ND4L | regulates | gene | 0.70 |
| ERRα | activates | protein | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PGC1Α | data_in | dataset_row | 0.00 |
| h-var-5c4b90eeeb | targets | hypothesis | 1.00 |
| MST1 | interacts_with | gene | 0.95 |
| 26363853 | exerts neuroprotective effects by promoting | paper | 0.90 |
| 26363853 | induces balanced expression of by binding to promoters of | paper | 0.90 |
| 26363853 | controls | paper | 0.90 |
| 26363853 | induces balanced expression of | paper | 0.90 |
| PPARGC1A | encodes | gene | 0.80 |
| MST1 | interacts_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation | 0.666 | neurodegeneration | Does LRRK2's role as a lysosomal volume |
| TFEB-PGC1α Mitochondrial-Lysosomal Decoupling | 0.622 | neurodegeneration | Gene expression changes in aging mouse b |
| PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi | 0.455 | neurodegeneration | Why does PRKN-mediated mitophagy, typica |
| Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.380 | developmental neurobiology | Do perinatal immune challenges create pe |
| Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.351 | developmental neurobiology | Do perinatal immune challenges create pe |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing | exploratory | myocardial infarction | 0.900 | 0.00 | R26-LSL-TFEB+/+; Acta2-cre mic | proposed | N/A |
| Trehalose-induced lysosomal changes and TFEB activation | exploratory | motoneuron degeneration | 0.900 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Trehalose-induced lysosomal membrane permeabilization and TFEB activat | exploratory | motoneuron degeneration | 0.900 | 0.00 | NSC34 neuroblastoma cells | proposed | N/A |
| PGC-1α knockout effects on PV+ interneuron maturation | validation | 0.900 | 0.00 | PGC-1α knockout mice | proposed | N/A | |
| TFEB silencing and misfolded protein degradation | exploratory | motoneuron degeneration | 0.880 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Protein expression analysis and cell migration assays in cardiac fibro | exploratory | cardiac fibrosis | 0.880 | 0.00 | primary cardiac fibroblasts fr | proposed | N/A |
| Functional validation of trehalose effects on misfolded protein cleara | exploratory | motoneuron degeneration diseas | 0.850 | 0.00 | cell models expressing misfold | proposed | N/A |
| ChIP-qPCR validation of TFEB binding to Thbs1 promoter | exploratory | cardiac fibrosis | 0.850 | 0.00 | mouse cardiac fibroblasts | proposed | N/A |
| Trehalose analog testing for autophagy induction | exploratory | motoneuron degeneration | 0.820 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| PGC-1α expression analysis during PV+ interneuron development | exploratory | 0.800 | 0.00 | mouse cortex | proposed | N/A | |
| Activity-dependent regulation of PGC-1α in PV+ interneurons | exploratory | 0.800 | 0.00 | mouse cortical neurons | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| Longitudinal modeling of human neuronal aging reveals the contribution of the RC [PMID:38066314] | ["Lee S", "Oh Y", "Victor M", "Yang Y", | Nature aging | 2024 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
| Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] | Fujiya Y, Harada T, Sugawara Y, Akeda Y, | Scientific reports | 2021 | 0 |
| High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] | Helmuth B, Leichter JJ, Rotjan RD, Casti | Scientific data | 2020 | 0 |
| The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. [PMID:26968346] | ["Martini-Stoica H", "Xu Y", "Ballabio A | Trends in neurosciences | 2016 | 0 |
| The Lysosome as a Regulatory Hub. [PMID:27501449] | ["Perera R", "Zoncu R"] | Annual review of cell and deve | 2016 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PGC1Α in their description or question text
No additional research found