gene

KMT2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KMT2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

37Outgoing

29Incoming

0Experiments

0Debates

Summary

KMT2A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KMT2A
Full Name	MLL1 (Mixed-Lineage Leukemia 1)
Aliases	lysine methyltransferase 2A
Protein Family	SET1/MLL COMPASS Family
Protein Type	Transferase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	Nucleus
Molecular Weight	432 kDa
Pathways	oxidative stress response
UniProt ID	Q16586
GeneCards	KMT2A
Human Protein Atlas	KMT2A
Alzheimer's Disease	Altered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's Disease	May affect dopaminergic neuron survival through transcriptional mechanisms
Huntington's Disease	Involved in transcriptional dysregulation caused by mutant huntingtin protein
Associated Diseases	ALS
Interactions	ABCB1, AND, ANK3, BCL-2, CACNA1G, CANCER
KG Connections	66 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KMT2A — AlphaFold Q16586 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KMT2A — lysine methyltransferase 2A

gene · 594 words

→

MLL1 Histone H3K4 Methyltransferase (KMT2A)

protein · 526 words

→

Pathway Diagram

graph TD
    KMT2A["KMT2A"]
    Leukemia{"Leukemia"}
    KMT2A -->|"therapeutic target"| Leukemia
    Als{"Als"}
    KMT2A -->|"therapeutic target"| Als
    Carcinoma{"Carcinoma"}
    KMT2A -->|"activates"| Carcinoma
    Ms{"Ms"}
    KMT2A -->|"activates"| Ms
    Tumor{"Tumor"}
    KMT2A -->|"activates"| Tumor
    RUNX1["RUNX1"]
    KMT2A -->|"therapeutic target"| RUNX1
    BCL_2["BCL-2"]
    KMT2A -->|"inhibits"| BCL_2
    neurodegeneration["neurodegeneration"]
    KMT2A -->|"implicated in"| neurodegeneration
    BCL_2 -->|"inhibits"| KMT2A
    ETV6["ETV6"]
    ETV6 -->|"therapeutic target"| KMT2A
    MBD2["MBD2"]
    MBD2 -->|"activates"| KMT2A
    ABCB1["ABCB1"]
    ABCB1 -->|"activates"| KMT2A
    style KMT2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Schizophrenia	inhibits	disease	0.65
Autism	inhibits	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
CRH	inhibits	gene	0.60
PICALM	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
TREH	associated_with	gene	0.60
XPO1	associated_with	gene	0.60
NUP98	regulates	gene	0.60
PICALM	regulates	gene	0.60
RUNX1	therapeutic_target	gene	0.60
BCL-2	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Epigenetic	inhibits	pathway	0.60
GENES	inhibits	gene	0.60
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
AND	inhibits	gene	0.60
Ras	inhibits	protein	0.60
ALS	associated_with	disease	0.60
neurons	expressed_in	cell_type	0.60
NPM1	inhibits	gene	0.60
SHANK3	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
SETD1A	inhibits	gene	0.60
KMT2B	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
KMT2D	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
GENE EXPRESSION	inhibits	concept	0.50

Incoming (29)

Source	Relation	Type	Str
DNA	regulates	gene	0.60
MBD2	activates	gene	0.60
ABCB1	activates	gene	0.60
SETD1A	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
KMT2B	inhibits	gene	0.60
SHANK3	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
CRH	inhibits	gene	0.60
CDKN2A	expressed_in	gene	0.60
MAP2K2	expressed_in	gene	0.60
ATM	associated_with	gene	0.60
FOXP3	expressed_in	gene	0.60
TP53	associated_with	gene	0.60
RB1	associated_with	gene	0.60
CD8	expressed_in	gene	0.60
PTEN	associated_with	gene	0.60
PIK3CA	expressed_in	gene	0.60
TSC1	expressed_in	gene	0.60
DDX3X	associated_with	gene	0.60
BCL-2	inhibits	gene	0.60
ETV6	therapeutic_target	gene	0.60
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
PD-L1	expressed_in	gene	0.60
PD-1	expressed_in	gene	0.60
AUTISM	inhibits	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KMT2A in their description or question text

No additional research found