gene

NRP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

0Debates

Summary

NRP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, causes, associated with. Associated with Als, Cancer, Carcinoma. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRP1
Full Name	Neuropilin 1
Chromosome	10p11.22
Protein Type	Receptor
Function	is a multi-domain transmembrane protein
Molecular Weight	140 kDa
Exons	27
Pathways	Angiogenesis, Cholesterol, NF-kB signaling, Nf-Kb, Tgf-Β
UniProt ID	O14786
NCBI Gene ID	4800
Ensembl ID	ENSG00000099250
OMIM	602069
GeneCards	NRP1
Human Protein Atlas	NRP1
Associated Diseases	Als, Carcinoma, Diabetes, Hepatocellular Carcinoma, Type 2 Diabetes
Interactions	Actin, Akt, AKT, AND, ANG, APOE
KG Connections	77 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NRP1 — AlphaFold O14786 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

nrp1

gene · 2037 words

→

Neuropilin-1 (NRP1) Protein

protein · 526 words

→

Pathway Diagram

graph TD
    NRP1["NRP1"]
    Cardiovascular{"Cardiovascular"}
    NRP1 -->|"activates"| Cardiovascular
    NGF["NGF"]
    NRP1 -->|"activates"| NGF
    GAIN["GAIN"]
    NRP1 -->|"inhibits"| GAIN
    APOE["APOE"]
    NRP1 -->|"activates"| APOE
    SLC44A2["SLC44A2"]
    NRP1 -->|"activates"| SLC44A2
    RUNX1["RUNX1"]
    NRP1 -->|"activates"| RUNX1
    Tgf__(["Tgf-Beta"])
    NRP1 -->|"activates"| Tgf__
    neurodegeneration["neurodegeneration"]
    NRP1 -->|"implicated in"| neurodegeneration
    TRKA["TRKA"]
    TRKA -->|"interacts with"| NRP1
    ANG["ANG"]
    ANG -->|"activates"| NRP1
    style NRP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Carcinoma	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Als	causes	disease	0.65
Carcinoma	causes	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Opioid	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Chronic Pain	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Ngf	activates	protein	0.60
NGF	activates	gene	0.60
GAIN	inhibits	gene	0.60
CD14	associated_with	gene	0.60
RUNX1	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
ITGB1	activates	gene	0.60
NF-KB	activates	gene	0.60
IL-6	activates	gene	0.60
Nf-Kb	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
Collagen	activates	protein	0.60
Fibroblast	activates	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
Raf	activates	protein	0.60
Akt	activates	protein	0.60
GLI1	activates	gene	0.60
Notch	associated_with	pathway	0.60
ENDOSOMES	activates	gene	0.60
Actin	interacts_with	protein	0.60
Myosin	associated_with	protein	0.60
VEGF	inhibits	gene	0.60
CD8	causes	gene	0.60
CXCL10	causes	gene	0.60
NOTCH	associated_with	gene	0.60
AND	activates	gene	0.60
Notch	causes	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
APOE	activates	gene	0.60
SLC44A2	activates	gene	0.60

Incoming (21)

Source	Relation	Type	Str
C-MYC	activates	gene	0.60
ANG	activates	gene	0.60
DES	activates	gene	0.60
CD8	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
VEGF	inhibits	gene	0.60
HMGCR	activates	gene	0.60
TRKA	interacts_with	gene	0.60
VEGF	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
ITGB1	activates	gene	0.60
TREM2	causes	gene	0.60
CD14	causes	gene	0.60
NGF	activates	gene	0.60
GAIN	inhibits	gene	0.60
CANCER	activates	gene	0.60
NMNAT2	activates	gene	0.60
PCSK9	associated_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRP1 in their description or question text

No additional research found