gene

PRKAA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

239Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

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🧬 Gene Info

Gene Symbol	PRKAA2
Full Name	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2
Aliases	AMP-Activated Protein Kinase Catalytic Subunit Alpha 2
Chromosome	1p32.2
Protein Type	Serine/Threonine Kinase
Function	is a convergent pathomechanism across major neurodegenerative diseases, making PRKAA2 a high-priority therapeutic target.
Primary Expression	oligodendrocytes
Amino Acids	552 aa
Exons	12
Pathways	Autophagy, autophagy pathway, complement cascade, oxidative stress response, phagocytosis
Ensembl ID	ENSG00000162409
GeneCards	PRKAA2
Human Protein Atlas	PRKAA2
Associated Diseases	Alzheimer Disease, neurodegeneration
Known Drugs/Compounds	AICAR, metformin, Metformin, rapamycin
Interactions	ACOX1, ADIPOQ, AMPK, AND, App, ATG
KG Connections	238 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

gene · 1883 words

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Pathway Diagram

graph TD
    PRKAA2["PRKAA2"] -->|"interacts"| Tumor["Tumor"]
    PRKAA2["PRKAA2"] -->|"interacts"| Hepatitis["Hepatitis"]
    PRKAA2["PRKAA2"] -->|"activates"| Als["Als"]
    PRKAA2["PRKAA2"] -->|"activates"| Ms["Ms"]
    PRKAA2["PRKAA2"] -->|"interacts"| Ischemia["Ischemia"]
    PRKAA2["PRKAA2"] -->|"interacts"| Inflammation["Inflammation"]
    PPARA["PPARA"] -->|"interacts"| PRKAA2["PRKAA2"]
    ULK1["ULK1"] -->|"interacts"| PRKAA2["PRKAA2"]
    STX17["STX17"] -->|"interacts"| PRKAA2["PRKAA2"]
    SQSTM1["SQSTM1"] -->|"interacts"| PRKAA2["PRKAA2"]
    style PRKAA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (125)

Target	Relation	Type	Str
protein synthesis	inhibits	process	0.95
Amino Acid Insufficiency	mediates	phenotype	0.95
Protein Synthesis	inhibits	process	0.95
Metformin	therapeutic_target	drug	0.90
Alzheimer Disease	protects_against	disease	0.90
Alzheimer Disease	associated_with	disease	0.90
Protein Aggregation	regulates	process	0.90
PPARGC1A	activates	gene	0.85
Alzheimer's Disease	protects_against	disease	0.80
cognitive dysfunction	protects_against	phenotype	0.80
PPARGC1A	activates	gene	0.80
MTORC1	inhibits	protein	0.80
zonula occludens-1	upregulates	protein	0.75
Ms	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Fatty Liver	activates	disease	0.65
Ischemia	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
PHAGOCYTOSIS	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
SNARE	activates	gene	0.60
Mtor	interacts_with	pathway	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
EIF2A	expressed_in	gene	0.60
P62	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
SLC16A1	activates	gene	0.60

Incoming (114)

Source	Relation	Type	Str
Amino Acid Insufficiency	activates	phenotype	0.95
GCN2	phosphorylates	gene	0.90
metformin	activates	drug	0.85
SESN1	activates	gene	0.85
AICAR	activates	compound	0.85
Metformin	activates	drug	0.85
protein restriction	activates	process	0.75
AND	regulates	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
AMPK	targets	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
SLC22A4	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
EPHA4	expressed_in	gene	0.60
PLIN3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKAA2 in their description or question text

No additional research found