concept

METFORMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METFORMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

573Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	METFORMIN
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	ACETYLCHOLINE, aging, AGING, ALS, ALZHEIMER
Related Pathways	AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Metformin for Parkinson's Disease - Phase 2/3 Trial (NCT07229651)

clinical · 1298 words

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Pathway Diagram

graph TD
    METFORMIN["METFORMIN"]
    style METFORMIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    METFORMIN -->|"upregulates"| SIRT1([SIRT1])
    METFORMIN -->|"treats"| Hepatic_Steatosis["Hepatic Steatosis"]
    METFORMIN -->|"activates"| SIRT1_Mediated_Autophagy["SIRT1-Mediated Autophagy"]
    METFORMIN -->|"treats"| Cognitive_Impairment(Cognitive Impairment)
    METFORMIN -->|"activates"| AMPK([AMPK])
    METFORMIN -.->|"inhibits"| astrocyte_senescence["astrocyte senescence"]
    METFORMIN -->|"modulates"| Mitochondrial_Biogenesis["Mitochondrial Biogenesis"]
    METFORMIN -->|"modulates"| Mitochondrial_Dynamics["Mitochondrial Dynamics"]
    METFORMIN -.->|"protects against"| Hippocampal_Neurodegeneration["Hippocampal Neurodegeneration"]

Outgoing (376)

Target	Relation	Type	Str
Ribociclib-Induced Toxicity	treats	phenotype	0.95
AMPK	activates	protein	0.95
Cognitive Impairment	treats	phenotype	0.95
PRKAA1	activates	gene	0.95
Mitochondrial Respiratory Activity	associated_with	process	0.95
Autophagy	associated_with	process	0.95
SIRT1-Mediated Autophagy	activates	pathway	0.95
Redox Homeostasis	associated_with	process	0.95
Mitochondrial Bioenergetics	associated_with	process	0.95
astrocyte senescence	inhibits	process	0.95
Necroptosis	suppresses	process	0.95
SIRT1	upregulates	gene	0.95
Hepatic Steatosis	treats	disease	0.95
Cadmium Neurotoxicity	treats	disease	0.93
Pro-Inflammatory Pathways	associated_with	pathway	0.92
MCOLN1	suppresses	gene	0.90
Immune-Inflammatory Responses	modulates	process	0.90
Hyperglycemia	treats	disease	0.90
Hippocampal Neurodegeneration	protects_against	process	0.90
Insulin Resistance	treats	disease	0.90
PRKAA1/2	activates	gene	0.90
MCOLN1	downregulates	gene	0.90
Type 2 Diabetes	treats	disease	0.90
KRTAP	upregulates	gene	0.90
pro-inflammatory pathways	associated_with	pathway	0.90
Pruritus	treats	phenotype	0.90
Type 2 Diabetes	treats	disease	0.90
Insulin Resistance	associated_with	phenotype	0.90
Mitochondrial Biogenesis	modulates	process	0.90
Glucose Homeostasis	regulates	process	0.90
Glucose Homeostasis	associated_with	phenotype	0.90
Cognitive Impairment	protects_against	phenotype	0.90
mitochondrial function	regulates	process	0.90
insulin sensitivity	treats	phenotype	0.90
oxidative stress	associated_with	process	0.90
Mitochondrial Dynamics	modulates	process	0.90
dopamine neuron injury	prevents	phenotype	0.88
RIPK1	inhibits	gene	0.88
KRTAPS	upregulates	gene	0.88
Neuroinflammation	modulates	process	0.88
Mitochondrial Function	modulates	process	0.88
Oxidative Stress	associated_with	phenotype	0.87
ATP levels	upregulates	phenotype	0.85
Adenosine Monophosphate Kinase Signaling	activates	pathway	0.85
Helper T Cell 17 Pathway	downregulates	pathway	0.85
COL6A1	downregulates	gene	0.85
MMP7	downregulates	gene	0.85
Hair Regrowth	associated_with	phenotype	0.85
immune-inflammatory responses	modulates	process	0.85
neuroinflammation	suppresses	process	0.85

Incoming (197)

Source	Relation	Type	Str
PRKAA1	therapeutic_target	gene	0.90
PRKAA2	therapeutic_target	gene	0.90
AMPK	targets	gene	0.70
ENDOTHELIAL	causes	cell_type	0.65
CA1	protects_against	brain_region	0.65
GFAP	protects_against	gene	0.65
TH	causes	gene	0.65
AMPK	treats	gene	0.65
BDNF	associated_with	gene	0.65
TREM2	protects_against	gene	0.65
AMYLOID PLAQUES	protects_against	phenotype	0.65
MLKL	inhibits	gene	0.65
NEURONS	treats	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
DIABETES	associated_with	disease	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
NICOTINAMIDE	activates	drug	0.65
NICOTINAMIDE	treats	drug	0.65
CCL2	inhibits	gene	0.65
TNF	inhibits	gene	0.65
PARKINSON'S DISEASE	targets	disease	0.65
MLKL	activates	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
AKT	regulates	gene	0.65
DIABETES	targets	disease	0.65
HEPATOCYTES	treats	cell_type	0.65
ALZHEIMER	treats	disease	0.65
SYK	regulates	gene	0.65
CGAS	mediates	gene	0.65
DIABETES	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
PARKINSON'S DISEASE	participates_in	disease	0.55
AMPK	participates_in	gene	0.55
AMPK	associated_with	gene	0.55
ACHE	inhibits	concept	0.50
AUTOPHAGY	activates	process	0.50
Neurodegeneration	inhibits	disease	0.50
PRESENILIN	inhibits	protein	0.50
CELL DEATH	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
INFLAMMATION	associated_with	process	0.50
T CELL	inhibits	cell_type	0.50
AGING	protects_against	process	0.50
AGING	inhibits	process	0.50
TREM2	inhibits	gene	0.50
NEUROINFLAMMATION	inhibits	process	0.50
TREM2	regulates	gene	0.50
NEUROINFLAMMATION	regulates	process	0.50
NLRP3	activates	gene	0.50
MICROGLIA	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning METFORMIN in their description or question text

No additional research found