protein

TIM23

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIM23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

4Outgoing

4Incoming

0Experiments

0Debates

Summary

TIM23 is a core component of the mitochondrial protein import machinery (TIM23 complex), essential for importing proteins into the mitochondrial inner membrane. It is critical for neuronal health and implicated in Parkinson's and Alzheimer's disease pathogenesis.

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🔬 Protein Info

Gene Symbol	TIM23
Aliases	TIM23 complex
Function	Given the central role of mitochondria in neuronal function—particularly in high-energy demanding dopaminergic neurons and other neuronal subtypes—TIM23-mediated protein import is fundamental to ne...
Subcellular Localization	inner mitochondrial membrane
Molecular Weight	16 kDa
Pathways	mitophagy
GeneCards	TIM23
Human Protein Atlas	TIM23
Associated Diseases	Parkinson's disease, Alzheimer's disease
Interactions	HSP60, NDP52, OPTINEURIN, PINK1
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

TIM23 Protein (Translocase of Inner Mitochondrial Membrane 23)

protein · 1557 words

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Pathway Diagram

flowchart TD
    TIM23(["TIM23"])
    OPTINEURIN(["OPTINEURIN"])
    HSP60(["HSP60"])
    mitophagy["mitophagy"]
    Autophagy("Autophagy")
    NDP52(["NDP52"])

    TIM23 -->|"activates"| OPTINEURIN
    TIM23 -->|"activates"| HSP60
    TIM23 -->|"activates"| mitophagy
    Autophagy -->|"activates"| TIM23
    NDP52 -->|"activates"| TIM23

    style TIM23 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
PINK1	interacts_with	protein	0.90
OPTINEURIN	activates	protein	0.50
HSP60	activates	protein	0.50
mitophagy	activates	pathway	0.50

Incoming (4)

Source	Relation	Type	Str
mitochondrial membrane potential loss	inhibits	phenotype	0.85
PINK1	interacts_with	gene	0.70
Autophagy	activates	process	0.50
NDP52	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIM23 in their description or question text

No additional research found