| Gene Symbol | ent-gene-1f51bfd1 |
| Subcellular Localization | . This domain contains multiple phosphorylation sites and interaction motifs |
| ATP binding | The kinase domain binds ATP in a conserved pocket, with affinity in the low micromolar range |
| Substrate recognition | PINK1 preferentially phosphorylates serine and threonine residues followed by acidic residues (Ser/Thr-X-Glu/Asp) |
| Autophosphorylation | PINK1 undergoes autophosphorylation at multiple sites, which is required for full activity |
| Downstream targets | Key substrates include ubiquitin (at Ser65), Parkin (at Ser65), and numerous mitochondrial proteins |
| Onset age | Typically 20-40 years, earlier than idiopathic PD |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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