entity

TOM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

22Hypotheses

0Analyses

2Outgoing

1Incoming

0Experiments

0Debates

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Wiki Pages (8)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
PINK1	binds	protein	0.90
PINK1 retention	promotes	phenotype	0.85

Incoming (1)

Source	Relation	Type	Str
PINK1	binds	gene	0.80

Targeting Hypotheses (22)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte	0.839	neurodegeneration	View
TREM2 Crosstalk and Synergistic Activation of Phagocytic Tra	0.740	neuroinflammation	What molecular mechanisms mediate SPP1-i
Metabolic-Support Secretome Dysfunction	0.730	neurodegeneration	Which specific factors in conditioned me
SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M	0.720	neurodegeneration	How can senescent microglia be molecular
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode

H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neurona	0.670	neurodegeneration	Investigate mechanisms of epigenetic rep
Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-	0.662	-	Blood-brain barrier permeability changes
TOM/TIM Complex Disruption Triggering Mitochondrial Integrat	0.622	neurodegeneration	What upstream mechanisms cause TDP-43 to
Spatial Transcriptome-Guided Precision Cell Therapy	0.578	neurodegeneration	Cell type vulnerability in Alzheimer's D
Circulating Endothelial Microparticles Expressing Activated	0.565	-	What blood-brain barrier permeability ch
AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal	0.520	neurodegeneration	epigenetic reprogramming aging neurons
Hippocampal-Cortical Transcriptomic Divergence Reveals Accel	0.519	Alzheimer disease	Allen Mouse Brain Aging Atlas: cross-age
Transcriptome-wide competition determines functional selecti	0.509	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa	0.440	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
Oligodendrocyte Precursor Cell Activation to Restore Structu	0.411	connectomics	Human connectome alterations in Alzheime
TREM2-Mediated Microglial Regulation of Oligodendrocyte Prec	0.385	connectomics	Human connectome alterations in Alzheime
Microglia-Mediated Synaptic Pruning Modulation to Optimize F	0.380	connectomics	Human connectome alterations in Alzheime
Astrocyte-Mediated Synaptic Pruning to Optimize Functional C	0.354	connectomics	Human connectome alterations in Alzheime
Pre-Symptomatic Dawn-Administration for Phase-Advance Target	0.335	-	What is the optimal dosage and timing of
Multi-Clock Ensemble Discordance as a Parkinson's Disease Pr	0.323	-	Epigenetic clocks as biomarkers for Alzh
Tissue-specific interactome destabilization drives phenotype	0.280	Mendelian neurological diseases (neurodegeneration)	What molecular mechanisms drive tissue-s
AD Polygenic Risk Score predicts transcriptomic aging accele	0.280	-	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TOM in their description or question text

H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neuronal Transcriptomic Dri

Score: 0.670 · neurodegeneration · 2026-04-22

## Mechanistic Overview H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neuronal Transcriptomic Drift starts from t

Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-β as Sentinel Event

Score: 0.662 · unknown disease · 2026-04-26

CSF soluble PDGFR-β shedding from pericytes as the earliest detectable molecular event in AD, preceding amyloid/tau path

TOM/TIM Complex Disruption Triggering Mitochondrial Integrated Stress Response (

Score: 0.622 · neurodegeneration · 2026-04-21

## Mechanistic Overview TOM/TIM Complex Disruption Triggering Mitochondrial Integrated Stress Response (mtISR) starts fr

Spatial Transcriptome-Guided Precision Cell Therapy

Score: 0.578 · neurodegeneration · 2026-04-04

## Mechanistic Overview Spatial Transcriptome-Guided Precision Cell Therapy starts from the claim that modulating SOX10

Circulating Endothelial Microparticles Expressing Activated LRP1 and CD31 Identi

Score: 0.565 · unknown disease · 2026-04-26

Cerebral microvascular endothelial cells shed submicron microparticles (EMPs) upon activation or apoptosis. EMPs carry s

AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Witho

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Without Altering Glia

Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegenera

Score: 0.519 · Alzheimer disease · 2026-04-24

## Mechanistic Overview Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegeneration-Like Signat

Transcriptome-wide competition determines functional selectivity after direct bi

Score: 0.509 · molecular neurobiology · 2026-04-25

lncRNA-0021 may not be uniquely specific at the physical binding level; instead, its apparent selectivity for mmu-miR-63

Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propagation

Score: 0.440 · neurodegeneration · 2026-04-26

Enteric α-synuclein misfolding spreads retrogradely via vagal afferents to DMV, then progressively to SNc (Braak stages

Oligodendrocyte Precursor Cell Activation to Restore Structural Connectome Integ

Score: 0.411 · connectomics · 2026-04-25

Oligodendrocyte Precursor Cell Activation to Restore Structural Connectome Integrity

TREM2-Mediated Microglial Regulation of Oligodendrocyte Precursor Cell Maturatio

Score: 0.385 · connectomics · 2026-04-26

This hypothesis proposes that microglial TREM2 activation serves as a master regulator that coordinates both synaptic pr

Microglia-Mediated Synaptic Pruning Modulation to Optimize Functional Connectome

Score: 0.380 · connectomics · 2026-04-27

This hypothesis proposes that targeted modulation of microglial synaptic pruning activity can restore optimal functional

Astrocyte-Mediated Synaptic Pruning to Optimize Functional Connectome Efficiency

Score: 0.354 · connectomics · 2026-04-26

Astrocytes play a critical role in synaptic pruning and maintenance of neural circuits through complement-mediated elimi

Pre-Symptomatic Dawn-Administration for Phase-Advance Targeting

Score: 0.335 · unknown disease · 2026-04-26

Morning administration of 0.3-0.5mg melatonin in early cognitive decline produces circadian phase advances that countera

Multi-Clock Ensemble Discordance as a Parkinson's Disease Prodrome Detector — Ep

Score: 0.323 · unknown disease · 2026-04-25

Concise Statement: In Parkinson's disease, different epigenetic clock algorithms (Horvath, Hannum, PhenoAge, GrimAge) g

TOM