Contents

MMP2 Gene

🧬 Gene Info

Gene Symbol	MMP2
Full Name	Matrix Metallopeptidase 2
Chromosome	16q13
Protein Type	Protease
Target Class	Protease
Function	MMP-2 (gelatinase A) degrades gelatin (denatured collagen), type IV collagen, and elastin.
Mechanism of Action	Small molecule zinc-chelating inhibitors of metalloprotease activity
Primary Expression	neurons, astrocytes, microglia, and endothelial cells where it regulates synaptic plasticity, blood-brain
Druggability	Medium (0.46)
Clinical Stage	Phase III
Molecular Weight	73.9 kDa
Amino Acids	660 aa
Pathways	Akt, Amyloid, Nf-Κb, Pi3K, Sleep-Wake Cycle
UniProt ID	P08253
Ensembl ID	ENSG00000196547
GeneCards	MMP2
Human Protein Atlas	MMP2
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Melatonin
Interactions	ADAMTS1, AEP, AGING, AGO2, AKT, AKT1
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	794 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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