Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Diseases | contributes_to | disease | 0.80 |
| Dementia Risk | contributes_to | phenotype | 0.80 |
| MAPK | activates | pathway | 0.80 |
| Major Depressive Disorder | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 30820047 | implicated in | paper | 0.90 |
| Dysfunctional Mitochondria Elimination | modulates | process | 0.85 |
| Autophagy | involved_in | process | 0.85 |
| Ferroptosis | associated_with | process | 0.80 |
| NF-κB | participates_in | pathway | 0.80 |
| LOXL3 | regulates | gene | 0.80 |
| Non-canonical Autophagy | involved_in | pathway | 0.80 |
| MDM2 | regulates | protein | 0.75 |
| LC3-associated phagocytosis | associated_with | process | 0.70 |
| IL17 | regulates | pathway | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train | 0.712 | neuroinflammation | What specific astrocyte-derived factors |
| LPS-primed microglial trained immunity establishes persisten | 0.670 | neurodegeneration | Synaptic pruning by microglia in neurode |
| SPP1+ DAM as Source of Autoimmunity in Neurodegeneration | 0.660 | Alzheimer's disease | - |
| Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis | 0.644 | developmental neurobiology | Do perinatal immune challenges create pe |
| Combine Anti-AQP4 Autoimmunity Control with Astrocyte-Endfoo | 0.630 | neurodegeneration | How can AQP4 be effectively targeted the |
| Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.380 | developmental neurobiology | Do perinatal immune challenges create pe |
| Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis | 0.351 | developmental neurobiology | Do perinatal immune challenges create pe |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.601
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513
neuroinflammation | 2026-04-13 | 0 hypotheses
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.701
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.74 · 2026-04-16
closed · Rounds: 4 · Score: 0.83 · 2026-04-15
closed · Rounds: 4 · Score: 0.75 · 2026-04-15
closed · Rounds: 4 · Score: 0.66 · 2026-04-13
closed · Rounds: 4 · Score: 0.79 · 2026-04-13
Hypotheses and analyses mentioning immunity in their description or question text
Score: 0.380 · developmental neurobiology · 2026-04-27
The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms
Score: 0.351 · developmental neurobiology · 2026-04-26
The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms