protein

P53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2576Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

P53 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 1671 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P53
Subcellular Localization	</th><td>Nucleus (transcription factor)</td></tr>
Pathways	Aging
GeneCards	P53
Human Protein Atlas	P53
N-terminal Transactivation Domain (TAD)	Contains two subdomains (TAD1, TAD2) for transcriptional activation
Proline-Rich Domain (PRD)	Mediates protein-protein interactions
Central DNA-Binding Domain (DBD)	Binds to p53 response elements (p53 RE) as a tetramer
Oligomerization Domain (OD)	Forms tetramers essential for DNA binding
C-terminal Regulatory Domain (CTD)	Modulates DNA binding and contains nuclear localization signals
Cell Cycle Arrest	Activates p21 to halt cell cycle progression
[Apoptosis](/entities/apoptosis)	Induces pro-apoptotic genes (BAX, PUMA, NOXA)
DNA Repair	Upregulates DNA repair proteins
Senescence	Induces cellular senescence programs
Metabolism	Modulates glycolysis and oxidative phosphorylation
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	APR-246, chemotherapy, Emodin, MDM2 antagonist Nutlin-3, rapamycin, RAPAMYCIN
Interactions	ACAT1, ACETYL-COA, ACOX1, ACSL4, Actin, ACVR2A
KG Connections	2543 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P53["P53"] -->|"activates"| PUMA["PUMA"]
    P53["P53"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    P53["P53"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    P53["P53"] -->|"regulates"| CELL_CYCLE["CELL_CYCLE"]
    P53["P53"] -->|"mediates"| ALS["ALS"]
    P53["P53"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    TP53["TP53"] -->|"encodes"| P53["P53"]
    POLY_PR["POLY_PR"] -->|"activates"| P53["P53"]
    SF3B1["SF3B1"] -->|"therapeutic target"| P53["P53"]
    TERT["TERT"] -->|"therapeutic target"| P53["P53"]
    style P53 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1544)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
P53	encodes	protein	0.00
CANCER	therapeutic_target	gene	1.00
Glycolysis	activates	pathway	1.00
MDM2	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	interacts_with	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Nf-Κb	activates	pathway	1.00
DNA	regulates	gene	1.00
Neurodegeneration	activates	disease	1.00
GENES	regulates	gene	1.00
Inflammation	inhibits	disease	1.00
Cancer	regulates	disease	1.00
CANCER	regulates	gene	1.00
Senescence	regulates	disease	1.00
INFLAMMATION	regulates	gene	1.00
Aging	therapeutic_target	disease	1.00
Autophagy	activates	pathway	1.00
DNA	inhibits	gene	1.00
Cell Cycle	regulates	pathway	1.00
Als	activates	disease	1.00
Als	treats	disease	1.00
Stem Cell	activates	pathway	1.00
FERROPTOSIS	activates	gene	1.00
Cancer	causes	disease	1.00
Tumor	therapeutic_target	disease	1.00
Cell Cycle	inhibits	pathway	1.00
CANCER	inhibits	gene	1.00
Dna Repair	inhibits	pathway	1.00
AGING	activates	gene	1.00
Cancer	associated_with	disease	1.00
Cancer	inhibits	disease	1.00
Oxidative Stress	inhibits	pathway	1.00
DNA	activates	gene	1.00
Tumor	inhibits	disease	1.00
Apoptosis	activates	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Tumor	associated_with	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
AKT	activates	gene	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Als	therapeutic_target	disease	1.00
PUMA	activates	protein	1.00
AKT	regulates	gene	1.00
Als	inhibits	disease	1.00
Mtor	regulates	pathway	1.00
Senescence	activates	disease	1.00

Incoming (1032)

Source	Relation	Type	Str
P53	encodes	gene	0.00
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
ROS	activates	gene	1.00
DNA	inhibits	gene	1.00
CYTOKINES	activates	gene	1.00
BAX	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
SLC7A11	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
NF-ΚB	activates	gene	1.00
CANCER	inhibits	gene	1.00
CANCER	expressed_in	gene	1.00
CANCER	activates	gene	1.00
GENES	inhibits	gene	1.00
TP53	inhibits	gene	1.00
ROS	inhibits	gene	1.00
SIRT1	activates	gene	1.00
TP53	therapeutic_target	gene	1.00
CANCER	targets	gene	1.00
TP53	regulates	gene	1.00
TP53	expressed_in	gene	1.00
APOPTOSIS	inhibits	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
PI3K	activates	gene	1.00
PI3K	associated_with	gene	1.00
CANCER	regulates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
MDM2	associated_with	protein	0.95
ribosomal proteins	activates	protein	0.90
POLY(PR)	activates	protein	0.90
RBM28	binds	protein	0.90
SNORA13	upstream_of	process	0.90
STAU1	activates	protein	0.90
DRAGO (KIAA0247)	cooperates_with	gene	0.90
SIRT1	regulates	enzyme	0.90
APR-246	activates	drug	0.90
SIRT1	modulates	enzyme	0.90
MDM2 antagonist Nutlin-3	activates	drug	0.90
MDM2	regulates	gene	0.90
SIRT1	deacetylates	enzyme	0.90
MDM2	interacts_with	protein	0.90
GPX4	activates	gene	0.90
AMPK	activates	gene	0.90
GENES	activates	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90
NEURODEGENERATION	regulates	gene	0.90
PI3K	regulates	gene	0.90
NEURODEGENERATION	associated_with	gene	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.842	ALS	-
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P53 in their description or question text

No additional research found

P53

Understanding Entity Pages

Summary

Wiki Pages (6)

Tumor Protein P53

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

DJ-1-PTEN-P53 Network

TP53 Gene

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

TP53 Protein (p53)

Pathway Diagram

Outgoing (1544)

Incoming (1032)

Targeting Hypotheses (2)

Mentioning Analyses (1)

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (0)

Debates (8)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Senescent cell clearance as neurodegeneration therapy

Related Research