protein 1,091 words KG: LRP4PROTEIN
Contents

LRP4 Protein - LDL Receptor-Related Protein 4

🔬 Protein Info
Gene SymbolLRP4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight195 kDa
Amino Acids1725 aa
Exons33
PathwaysWnt signaling, Wnt
UniProt ID[Q9NPJ6](https://www.uniprot.org/uniprot/Q9NPJ6)
Ensembl IDENSG00000134538
GeneCardsLRP4
Human Protein AtlasLRP4
EGF-like Domains (2 domains)Two epidermal growth factor-like domains in the extracellular region provide structural support and ligand-binding versatility.
Ligand-Binding Repeats (4 domains)Four complement-type LDLR ligand-binding repeats form the primary ligand interaction surface.
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Cardiovascular
InteractionsCANCER, PAH, WNT
KG Connections68 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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