protein 813 words KG: LRP1BPROTEIN
Contents

LRP1B Protein - LDL Receptor-Related Protein 1B

🔬 Protein Info
Gene SymbolLRP1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
Ligand-binding repeats32-33 complement-type repeats that bind various ligands
O-linked sugar domainThreonine/serine-rich region
Single pass transmembrane helixSpans the plasma membrane
Associated DiseasesAging, Als, Atherosclerosis, cancer
InteractionsAPOE, APOPTOSIS, CANCER, LDL, PAH, PD-1
KG Connections100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (17)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72

Related Analyses (11)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 6 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
Cerebral Amyloid Angiopathy Pathway in Neurodegeneratio
mechanism · Pages share 6 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses

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