| Gene Symbol | LDLR |
| Aliases | LDLRPROTEIN |
| Chromosome | 19p13.2 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | LDL Binding: Extracellular domain binds circulating LDL (containing cholesterol and triglycerides) |
| Mechanism of Action | Upregulation through PCSK9 inhibition or direct receptor modulation |
| Druggability | High (0.75) |
| Clinical Stage | Approved |
| Amino Acids | 860 aa |
| Exons | 18 |
| Pathways | Cholesterol, Cholesterol Metabolism, Complement, EGFR_signaling, Endocytosis |
| UniProt ID | H0YMD1 |
| Ensembl ID | ENSG00000130164 |
| GeneCards | LDLR |
| Human Protein Atlas | LDLR |
| Associated Diseases | ADH, Aging, Als, Alzheimer |
| Known Drugs/Compounds | 25-Hydroxycholesterol, lipid_lowering_medications, statins |
| Interactions | AB, ABCA1, abca2, ABCA2, ACETYL-COA, Actin |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | FcRn Transport Bypass Strategy LRP1-Mediated Endosomal Escape Enhancement Strateg LDLR-Targeted Anti-Inflammatory Antibody Delivery (+6 more) |
| KG Connections | 1224 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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